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首页> 外文期刊>Life sciences >Effects of excess salt and fat intake on myocardial function and infarct size in rat
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Effects of excess salt and fat intake on myocardial function and infarct size in rat

机译：盐和脂肪摄入过多对大鼠心肌功能和梗塞面积的影响

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Important risk factors for cardiovascular disease include excess dietary intake of saturated fat and (or) salt. This study tested the hypothesis that excess intakes of saturated fat (e.g., beef tallow) and salt cause greater myocardial cell death following ischemia-reperfusion injury than each risk factor alone. Male rats were divided into four groups: basal fat diet (4.5% as calories; control), high fat diet (40% as calories; FAT), basal fat diet and high salt (1% NaCl solution; SALT) and high fat diet and high salt (FATSALT). The gain in body weight was significantly higher for FAT and FATSALT groups than those of either the control or the SALT group. Five weeks of exposure to the dietary regimens did not significantly affect the coronary flow rate and except for the salt-fed group, had no effect on the rate-pressure-product of the isolated heart perfused in Langendorff mode. Although infarct size was not affected by the high fat diet, it was reduced by the high salt regimen relative to the high fat diet or the control groups. When rats were fed the FAT and SALT combination, the effect of salt feeding on infarct size was not observed. In addition, the FATSALT group displayed a more marked deterioration in contractile function following ischemia-reperfusion injury than the other groups. In conclusion, short-term intake of a high fat diet, which significantly increases body weight, does not worsen ischemia-reperfusion injury although the treatment prevents the reduction of infarct size associated with high salt feeding. (c) 2005 Elsevier Inc. All rights reserved.
机译：心血管疾病的重要危险因素包括饮食中摄入过多的饱和脂肪和（或）盐。这项研究检验了以下假设，即饱和脂肪（例如牛脂）和盐的摄入过多会导致缺血再灌注损伤后心肌细胞死亡的危险大于单独的每种危险因素。雄性大鼠分为四组：基础脂肪饮食（卡路里为4.5％;对照组），高脂肪饮食（卡路里为40％; FAT），基础脂肪饮食和高盐（1％NaCl溶液; SALT）和高脂肪饮食和高盐（FATSALT）。 FAT和FATSALT组的体重增加显着高于对照组或SALT组的体重增加。饮食方案暴露五周对冠状动脉流速没有显着影响，除食盐组外，对以Langendorff模式灌注的离体心脏的速率-压力乘积没有影响。尽管高脂饮食不影响梗塞面积，但相对于高脂饮食或对照组，高盐饮食可以减少梗塞面积。当给大鼠饲喂FAT和SALT组合时，未观察到食盐对梗塞面积的影响。此外，与其他组相比，FATSALT组在缺血再灌注损伤后的收缩功能恶化更为明显。总之，短期摄入高脂饮食可显着增加体重，但不会使缺血-再灌注损伤恶化，尽管这种治疗可以防止因高盐喂养而导致的梗塞面积减少。 （c）2005 Elsevier Inc.保留所有权利。

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