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首页> 外文期刊>Life sciences >STRAIN- AND SEX-RELATED DIFFERENCES OF ACETOHEXAMIDE REDUCTASE ACTIVITIES IN LIVER MICROSOMES AND CYTOSOL OF RATS - THE WISTAR-IMAMICHI STRAIN LACKS THE MALE-SPECIFIC MICROSOMAL ENZYME ACTIVITY
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STRAIN- AND SEX-RELATED DIFFERENCES OF ACETOHEXAMIDE REDUCTASE ACTIVITIES IN LIVER MICROSOMES AND CYTOSOL OF RATS - THE WISTAR-IMAMICHI STRAIN LACKS THE MALE-SPECIFIC MICROSOMAL ENZYME ACTIVITY

机译：大鼠肝微粒体和细胞溶胶中乙酰胺还原酶活性的应变和性别相关差异-WISTAR-IMAMICHI菌株缺乏男性特定的微生物酶活性

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A marked strain-related difference was observed among acetohexamide reductase activities in liver microsomes of male rats. The microsomal enzyme activities in the Fischer-344 (Fischer), Sprague-Dawley (SD) and Wistar strains were 2.58+/- 0.50, 1.60+/-0.44 and 0.79+/-0.41 nmol/min/mg protein, respectively. The microsomal enzyme activities in these rat strains were much higher in males than in females, indicating that the microsomal enzyme is a male-specific enzyme. The Wistar-Imamichi (Wistar-IM) strain was found to lack the male-specific microsomal enzyme activity. In Fischer, SD and Wistar strains of testectomized male rats, the microsomal enzyme activities were significantly increased by the treatment with testosterone. However, testosterone treatment was ineffective on the microsomal enzyme activity in the Wistar-IM strain. These results suggest that Wistar-IM rats has a genetic deficiency of the microsomal enzyme. There was no strain-related difference among the cytosolic enzyme activities in male rats. The cytosolic enzyme activities in Fischer and Wistar rats were higher in females than in males. [References: 29]
机译：在雄性大鼠肝微粒体中，乙氧基乙酰胺还原酶活性之间存在明显的应变相关差异。 Fischer-344（Fischer），Sprague-Dawley（SD）和Wistar菌株中的微粒体酶活性分别为2.58 +/- 0.50、1.60 +/- 0.44和0.79 +/- 0.41 nmol / min / mg蛋白。这些大鼠品系中的微粒体酶活性在雄性中比雌性中高得多，表明微粒体酶是雄性特异性酶。发现Wistar-Imamichi（Wistar-IM）菌株缺乏雄性特异性微粒体酶活性。在睾丸切除的雄性大鼠的Fischer，SD和Wistar品系中，通过睾丸激素治疗可显着提高微粒体酶的活性。但是，睾丸激素处理对Wistar-IM菌株的微粒体酶活性无效。这些结果表明Wistar-IM大鼠具有微粒体酶的遗传缺陷。在雄性大鼠中，胞质酶活性之间没有与菌株相关的差异。雌性Fischer和Wistar大鼠的胞质酶活性高于雄性。 [参考：29]

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