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AUDITORY AND VISUAL P300 EVENT RELATED POTENTIALS ARE NOT ALTERED IN MEDICALLY AND PSYCHIATRICALLY NORMAL CHRONIC MARIHUANA USERS

机译:在医学和心理上正常的慢性大麻使用者中,音频和视觉P300事件相关电位未改变

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Attempts to use Event Related Potentials, particularly the cognitive or P300 evoked potential, as measures of CNS effects of THC use have been infrequent and have produced inconsistent results. We published a pilot study in which psychiatric patient THC users had significantly prolonged auditory P300 latencies and reduced amplitudes as contrasted with non-users. Because psychiatric diagnoses and medication effects could not be controlled, we repeated the study with medically and psychiatrically normal subjects selected with extremely stringent exclusion criteria and screening procedures. P300 latency differences between THC users and controls were not detected. Using all subjects, THC users displayed reduced auditory and visual P300 amplitudes. However, when age differences between THC users and controls were removed, all significant P300 amplitude differences were removed as well. The contaminating effect of using psychiatric patients in THC research is discussed and the importance of using carefully screened normal subjects in studies of neurophysiological abuse drug effects is stressed. [References: 17]
机译:尝试使用事件相关电位,尤其是认知电位或P300诱发电位,因为使用THC的中枢神经系统作用的测量很少,并且产生的结果不一致。我们发表了一项前瞻性研究,其中与非使用者相比,精神病患者THC使用者的听觉P300潜伏期显着延长,振幅降低。由于无法控制精神病学的诊断和药物治疗效果,因此我们以严格的排除标准和筛查程序对医学和精神病学正常的受试者进行了重复研究。未检测到THC用户和控件之间的P300延迟差异。使用所有主题,THC用户显示出听觉和视觉上P300振幅降低。但是,当THC用户和对照组之间的年龄差异被消除时,所有显着的P300幅度差异也将被消除。讨论了在THC研究中使用精神病患者的污染效应,并强调了在神经生理滥用药物效应研究中使用经过仔细筛选的正常受试者的重要性。 [参考:17]

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