ENDOGENOUS TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY A PANCREATIC BETA-CELL LINE - INHIBITORY EFFECTS OF HYDROCORTISONE AND NICOTINAMIDE

Yamada K.; Inada C.; Nonaka K.; Takanegyotoku N.

首页> 外文期刊>Life sciences >ENDOGENOUS TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY A PANCREATIC BETA-CELL LINE - INHIBITORY EFFECTS OF HYDROCORTISONE AND NICOTINAMIDE

【24h】

ENDOGENOUS TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY A PANCREATIC BETA-CELL LINE - INHIBITORY EFFECTS OF HYDROCORTISONE AND NICOTINAMIDE

机译：胰β-细胞系生产内源性肿瘤坏死因子-氢化可的松和烟酰胺的抑制作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The purpose of this study was to examine regulation of interleukin-1(IL-1)-induced tumor necrosis factor-alpha (TNF-alpha) production by a mouse beta-cell line (beta TC1). Three-hour incubation of beta TC1 cells with 5 U/ml of IL-1 beta results in the expression of TNF-alpha mRNA and intracellular accumulation of TNF-alpha. It has been shown that glucocorticoids and immunosuppressive agents such as cyclosporin and FK-506 inhibit TNF-alpha generation by T-lymphocytes and monocytes. Hydrocortisone of 1 and 10 mu mol/l suppressed TNF-alpha mRNA levels and the TNF-alpha content of beta TC1 cells exposed to IL-1 beta, whereas neither cyclosporin nor FK-506 altered the TNF-alpha content. Nicotinamide of 5-10 mmol/l also reduced TNF-alpha mRNA and TNF-alpha protein levels in beta TC1 cells. Addition of exogenous TNF-alpha did not inhibit IL-1-induced transcription of TNF-alpha gene. These observations support the potential therapeutic role of glucocorticoids and nicotinamide in protecting beta-cells against cytokine-mediated damage, although glucocorticoid agonists have hyperglycemic metabolic effects. [References: 29]

机译：这项研究的目的是检查小鼠白细胞（βTC1）对白介素-1（IL-1）诱导的肿瘤坏死因子-α（TNF-α）产生的调节。 βTC1细胞与5 U / ml的IL-1β孵育3小时会导致TNF-αmRNA的表达和TNF-α的细胞内积累。已经显示，糖皮质激素和免疫抑制剂如环孢菌素和FK-506抑制T淋巴细胞和单核细胞产生TNF-α。 1和10μmol/ l的氢化可的松抑制暴露于IL-1β的βTC1细胞的TNF-αmRNA水平和TNF-α含量，而环孢菌素和FK-506均未改变TNF-α含量。 5-10 mmol / l的烟酰胺还可以降低βTC1细胞中的TNF-αmRNA和TNF-α蛋白水平。外源TNF-α的添加不会抑制IL-1诱导的TNF-α基因的转录。这些观察结果支持糖皮质激素和烟酰胺在保护β细胞免受细胞因子介导的损害中的潜在治疗作用，尽管糖皮质激素激动剂具有高血糖代谢作用。 [参考：29]

著录项

来源
《Life sciences》 |1996年第17期|共7页
作者
Yamada K.; Inada C.; Nonaka K.; Takanegyotoku N.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Pancreatic beta-cell; Tumor necrosis factor-alpha; Interleukin-1; Hydrocortisone; Cyclosporin; Fk-506; Nicotinamide; Messenger-rna induction; Nitric-oxide production; Interferon-gamma; Insulin release; Transgenic mice; Recent onset; Rat islets; Interleukin-1; Langerhans; Expression;

机译：胰腺β细胞;肿瘤坏死因子-α;白细胞介素-1;氢化可的松;环孢菌素;Fk-506;烟酰胺;Messenger-rna诱导;一氧化氮的产生;干扰素-γ;胰岛素释放;转基因小鼠;近期发作;大鼠胰岛;白介素-1;朗格汉斯;表达;

相似文献

外文文献
中文文献
专利

1. ENDOGENOUS TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY A PANCREATIC BETA-CELL LINE - INHIBITORY EFFECTS OF HYDROCORTISONE AND NICOTINAMIDE [J] . Yamada K., Inada C., Nonaka K., Life sciences . 1996,第17期

机译：胰β-细胞系生产内源性肿瘤坏死因子-氢化可的松和烟酰胺的抑制作用
2. Inhibitory effects of the stem bark of Catalpa ovata G. Don. (Bignoniaceae) on the productions of tumor necrosis factor-alpha and nitric oxide by the lipopolisaccharide-stimulated RAW 264.7 macrophages. [J] . Pae HO, Oh GS, Choi BM, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2003,第2a3期

机译：Catalpa ovata G. Don的茎皮的抑制作用。（洋紫薇）对脂多糖刺激的RAW 264.7巨噬细胞产生肿瘤坏死因子-α和一氧化氮的作用。
3. Inhibitory Effects of Chemical Compounds Isolated from the Rhizome of Smilax glabra on Nitric Oxide and Tumor Necrosis Factor-alpha Production in Lipopolysaccharide-Induced RAW264.7 Cell [J] . Lu Chuan-li, Zhu Wei, Wang Dong-mei, Evidence-based complementary and alternative medicine: eCAM . 2015,第3期

机译：从Smilax Glabra的根茎中分离的化学化合物对脂多糖诱导的Raw264.7细胞的一氧化氮和肿瘤坏死因子-α产生的抑制作用
4. Inhibitory Effects of a Rice Hull Constituent on Tumor Necrosis Factor, Prostaglandin E2, and Cyclooxygenase-2 Production in Lipopolysaccharide-Activated Mouse Macrophages [C] . SHENG-TUNG HUANG, CHIEN-TSU CHEN, KUR-TA CHIENG, Asian Society for Mitochondrial Research and Medicine . 2005

机译：稻壳组分对脂多糖活化小鼠巨噬细胞肿瘤坏死因子，前列腺素E2和环氧氧酶-2生产的抑制作用
5. Tumor necrosis factor-alpha and insulin interactions: Effects on leptin production and Akt expression in adipocytes. [D] . Medina, Edward Antonio. 2003

机译：肿瘤坏死因子-α和胰岛素的相互作用：对脂肪细胞中瘦素产生和Akt表达的影响。
6. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production [O] . 1995

机译：白细胞介素（IL）-4和IL-13对人外周血单核细胞产生细胞因子的刺激和抑制作用：引发IL-12和肿瘤坏死因子α的产生
7. Cytokines tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta-cell apoptosis through STAT1-mediated Bim protein activation. [O] . Barthson, Jenny, Germano, Carla M, Moore, Fabrice, 2011

机译：细胞因子肿瘤坏死因子-α和干扰素-γ通过STAT1介导的Bim蛋白激活诱导胰腺β细胞凋亡。
8. Production of Tumor Necrosis Factor-alpha, Interleukin 1-beta, Interleukin 2, and Interleukin 6 by Rat Leukocyte Subpopulations after Exposure to Substance P. [R] . Delgado, A. V., McManus, A. T., Chambers, J. P. 2003

机译：暴露于物质p后大鼠白细胞亚群产生肿瘤坏死因子-α，白细胞介素1-β，白细胞介素2和白细胞介素6

ENDOGENOUS TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY A PANCREATIC BETA-CELL LINE - INHIBITORY EFFECTS OF HYDROCORTISONE AND NICOTINAMIDE

摘要

著录项

相似文献

相关主题

期刊订阅