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首页> 外文期刊>Life sciences >Diazepam pretreatment suppresses morphine withdrawal signs in the mouse.
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Diazepam pretreatment suppresses morphine withdrawal signs in the mouse.

机译：地西p预处理可抑制小鼠的吗啡戒断症状。

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摘要

The effect of diazepam on the development of physical dependence on morphine and on the naloxone-precipitated increase in cortical NA turnover were investigated in mice. Co-administration of diazepam (1-4 mg/kg, i.p.) during chronic morphine treatment suppressed the expression of naloxone (3 mg/kg, s.c.)-precipitated withdrawal signs (jumping, exploratory rearing and weight loss). However, a single injection of diazepam (4 mg/kg, i.p.) in morphine-dependent mice did not affect the expression of naloxone-precipitated withdrawal signs. The 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) level and noradrenaline (NA) turnover (MHPG/NA) in the cerebral cortex were increased by naloxone (3 mg/kg) challenge. These increases in the cortical MHPG level and NA turnover were significantly prevented by co-administration of diazepam (4 mg/kg, i.p.) during chronic morphine treatment. These findings suggest that the co-administration of diazepam during chronic morphine treatment may prevent some neurochemical changes in the central noradrenergic system during chronic morphine treatment, and may suppress the development of physical dependence on morphine. Therefore, the inhibitory action of GABA via benzodiazepine binding sites may play an important role in the development of physical dependence on morphine.
机译：在小鼠中研究了地西epa对身体对吗啡的依赖性和对纳洛酮沉淀的皮质NA更新的增加的影响。慢性吗啡治疗期间并用地西epa（1-4 mg / kg，腹膜内）抑制了纳洛酮的表达（3 mg / kg，皮下）沉淀的戒断症状（跳跃，探索性抚养和体重减轻）。但是，在吗啡依赖性小鼠中单次注射地西epa（4 mg / kg，腹腔注射）不会影响纳洛酮沉淀的戒断症状的表达。纳洛酮（3 mg / kg）刺激可增加大脑皮层中的3-甲氧基-4-羟基苯基乙二醇（MHPG）水平和去甲肾上腺素（NA）转换（MHPG / NA）。慢性吗啡治疗期间并用地西epa（4 mg / kg，腹腔注射）可显着防止皮质MHPG水平和NA转换的增加。这些发现表明，在慢性吗啡治疗期间并用地西co可以预防慢性吗啡治疗期间中枢去甲肾上腺素能系统的某些神经化学变化，并可以抑制对吗啡的身体依赖性。因此，GABA通过苯并二氮杂pine结合位点的抑制作用可能在对吗啡的物理依赖性的发展中起重要作用。

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