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首页> 外文期刊>Life sciences >NATURAL IMMUNITY AND CHRONIC EXERCISE IN RATS - THE INVOLVEMENT OF THE SPLEEN AND THE SPLENIC NERVES
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NATURAL IMMUNITY AND CHRONIC EXERCISE IN RATS - THE INVOLVEMENT OF THE SPLEEN AND THE SPLENIC NERVES

机译：大鼠的自然免疫力和慢性运动-脾脏和脾脏神经的侵犯。

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摘要

We have previously shown that voluntary running for 4-5 weeks in the spontaneously hypertensive rat (SHR) significantly increased in natural cytotoxic mechanism in vivo, measured as clearance of Cr-51 YAC-1 lymphoma cells from the lungs. In the present study, we have studied the possible role of the spleen and the splenic nerves in this augmentation. The SHR were randomly allocated to either a voluntary exercise group or a sedentary control group. After four weeks of exercise the runners and sedentary control SHR were further assigned to one of four groups: 1) no surgery, 2) sham operation, 3) splenic nerve section and 4) splenectomy. Splenectomy drastically reduced in vivo cytotoxicity in both runners and sedentary controls, but in vivo cytotoxicity of splenectomized voluntary runners was significantly higher than that of splenectomized sedentary control animals. Selective denervation of the spleen did not affect the in vivo cytotoxicity. These results indicate that the enhanced in vivo natural cytotoxic mechanism following voluntary chronic exercise in SHR is partly dependent on intact splenic function. However, this enhancement does not seem to be mediated by the splenic sympathetic nerves. [References: 31]
机译：先前我们已经表明，以从肺中清除Cr-51 YAC-1淋巴瘤细胞的程度衡量，在自然发性高血压大鼠（SHR）中自愿跑步4-5周的体内自然细胞毒性机制显着增加。在本研究中，我们研究了脾脏和脾神经在这种增生中的可能作用。 SHR被随机分配到自愿运动组或久坐对照组。运动四个星期后，跑步者和久坐控制SHR被进一步分为四组之一：1）不做手术，2）假手术，3）脾神经节和4）脾切除术。脾切除术大大减少了跑步者和久坐对照的体内细胞毒性，但脾切除的自愿跑步者的体内细胞毒性显着高于脾切除的久坐对照动物。脾的选择性神经支配不影响体内细胞毒性。这些结果表明，在SHR中进行自愿性长期锻炼后，体内天然细胞毒性机制的增强部分取决于完整的脾功能。但是，这种增强似乎不是由脾交感神经介导的。 [参考：31]

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