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首页> 外文期刊>Life sciences >A PHORBOL ESTER THAT ACTIVATES PROTEIN KINASE C MIMICS THE ACTION OF ESTRADIOL OR EPIDERMAL GROWTH FACTOR FOR INITIATING EMBRYO IMPLANTATION IN THE DELAYED IMPLANTING HYPOPHYSECTOMIZED RAT
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A PHORBOL ESTER THAT ACTIVATES PROTEIN KINASE C MIMICS THE ACTION OF ESTRADIOL OR EPIDERMAL GROWTH FACTOR FOR INITIATING EMBRYO IMPLANTATION IN THE DELAYED IMPLANTING HYPOPHYSECTOMIZED RAT

机译：激活蛋白激酶C的Phorbol酯模拟雌二醇或表皮生长因子在延迟植入的经皮下注射电离的大鼠中启动胚胎着床的作用

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In rodents an action of estrogen is required for the initiation of implantation of the blastocyst into the endometrium of a progesterone-primed uterus. Thus removal of endogenous estrogen, either directly by ovariectomy or indirectly by hypophysectomy, prevents implantation in the pregnant rat. In the present study, delayed implanting hypophysectomized progesterone-primed rats were used to test the efficacy of cyclic adenosine 3',5'-monophosphate (cAMP), epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I), which are agents that have been shown to mimic some uterine actions of estradiol, to initiate implantation. In confirmation of previous studies, EGF injected into the uterine lumen plus intravenously was effective at initiating implantation in all animals. IGF-I showed no such activity in this model system. Cyclic AMP, increased via direct activation of adenylyl cyclase by forskolin, or administration of sodium dibutyryl cAMP, did not initiate implantation. However, a ligand for protein kinase C (PKC), phorbol la-myristate 13-acetate, was effective in augmenting the action of intrauterine EGF, or forskolin, for initiation of implantation. A phorbol ester that does not activate PKC was ineffective. The results provide circumstantial evidence for the requirement of PKC activity in the implantation initiating action of estrogens. [References: 34]
机译：在啮齿动物中，需要雌激素的作用才能将胚泡植入孕激素引发的子宫内膜。因此，直接通过卵巢切除术或通过垂体切除术间接去除内源性雌激素阻止了在怀孕大鼠中的植入。在本研究中，使用延迟植入经透水线切除的孕激素引发的大鼠来测试环腺苷3'，5'-单磷酸（cAMP），表皮生长因子（EGF）和胰岛素样生长因子-I（IGF-I）的功效），已被证明可模仿雌二醇的某些子宫作用以启动植入。为了证实先前的研究，将EGF注入子宫内腔并静脉内注射可有效启动所有动物的植入。 IGF-I在该模型系统中未显示此类活性。通过福司可林直接激活腺苷酸环化酶或施用二丁酰cAMP钠而增加的环AMP并未启动植入。但是，蛋白激酶C（PKC）的配体，豆蔻酸佛波醇13-乙酸盐，在增强子宫内EGF或毛喉素对植入的起始作用方面是有效的。不激活PKC的佛波酯无效。该结果为在雌激素的植入起始作用中PKC活性的需要提供了间接证据。 [参考：34]

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