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首页> 外文期刊>Life sciences >The effects of stress on alcohol consumption: mild acute and sub-chronic stressors differentially affect apomorphine susceptible and unsusceptible rats.
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The effects of stress on alcohol consumption: mild acute and sub-chronic stressors differentially affect apomorphine susceptible and unsusceptible rats.

机译：应激对饮酒的影响：轻度急性和亚慢性应激源差异性地影响阿扑吗啡敏感和不敏感的大鼠。

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摘要

The aim of this study was to investigate the effects of mild acute and mild sub-chronic challenges on alcohol intake and preference in the genetically selected ratlines of apomorphine susceptible (APO-SUS) and apomorphine unsusceptible (APO-UNSUS) animals. Animals from both lines were subjected to the 24 hr continuous alcohol vs. water paradigm under baseline conditions, after a single stressor and after multiple stressors. The intake of alcohol in ml was measured and converted to two values, namely intake in g/kg/24 hour of, and preference for, alcohol. This study shows that under baseline conditions the APO-UNSUS animals consume/prefer more alcohol than the APO-SUS animals. After an acute challenge the APO-SUS animals show a large increase in consumption, whereas the APO-UNSUS animals display only a small increase. Furthermore, sub-chronic challenges can further increase the consumption of the APO-UNSUS rat, but not that of the APO-SUS rat. The APO-SUS/ APO-UNSUS rats represent a good model to study the interaction between genetic factors and stress on directing alcohol consumption.
机译：这项研究的目的是研究轻度急性和轻度亚慢性挑战对阿朴吗啡敏感（APO-SUS）和阿扑吗啡不敏感（APO-UNSUS）动物的基因选择大鼠的酒精摄入和偏好的影响。来自两个品系的动物在基线条件下，单次应激后和多次应激后都经历了24小时连续酒精对水的实验。测量以毫升为单位的酒精摄入量，并将其转换为两个值，即以g / kg / 24小时为单位的摄入量，以及对酒精的偏爱。这项研究表明，在基线条件下，APO-UNSUS动物比APO-SUS动物消耗/偏爱更多的酒精。急性攻击后，APO-SUS动物的消耗量显示出大幅增加，而APO-UNSUS动物的消耗量显示出很小的增长。此外，亚慢性挑战可进一步增加APO-UNSUS大鼠的消耗，而不是APO-SUS大鼠的消耗。 APO-SUS / APO-UNSUS大鼠是研究遗传因素与指导饮酒压力之间相互作用的良好模型。

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