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首页> 外文期刊>Life sciences >Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test.
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Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test.

机译：对辣椒素敏感的传入神经消融会影响静脉葡萄糖耐量试验期间的胰岛素反应。

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摘要

We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measured. Higher glucose concentration resulted in a greater insulin response in both capsaicin- and vehicle-treated rats. However, glucose-stimulated insulin secretion was attenuated in capsaicin-treated animals, even though glucose levels did not differ. Glucagon levels did not differ between both groups. These results show that capsaicin-sensitive nerves are involved in glucose-stimulated insulin secretion, but are not directly involved in the regulation of blood glucose levels. Moreover, they suggest that capsaicin-sensitive nerves could be involved in the regulation of insulin sensitivity. We hypothesize that sensory afferents could play a role in the aetiology of pathologies where glucohomeostatic mechanisms are disturbed, as is in type 2 diabetes mellitus.
机译：我们调查了感觉神经在新生用神经毒素辣椒素或赋形剂治疗的Wistar大鼠的葡萄糖耐量中的作用。进行静脉葡萄糖耐量测试（IVGTT，在30分钟内进行150、300和450毫克）以测量葡萄糖耐量，并测量葡萄糖，胰岛素和胰高血糖素水平。较高的葡萄糖浓度在辣椒素和媒介物治疗的大鼠中导致更大的胰岛素反应。然而，即使葡萄糖水平没有差异，在辣椒素治疗的动物中葡萄糖刺激的胰岛素分泌也会减弱。两组之间的胰高血糖素水平没有差异。这些结果表明，对辣椒素敏感的神经参与葡萄糖刺激的胰岛素分泌，但不直接参与血糖水平的调节。此外，他们认为辣椒素敏感性神经可能参与胰岛素敏感性的调节。我们假设感觉传入可能在糖原稳态机制被破坏的病理学的病因中起作用，就像在2型糖尿病中一样。

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