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首页> 外文期刊>Life sciences >Effect of dietary sesame oil as antioxidant on brain hippocampus of rat in focal cerebral ischemia
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Effect of dietary sesame oil as antioxidant on brain hippocampus of rat in focal cerebral ischemia

机译：日粮麻油作为抗氧化剂对局灶性脑缺血大鼠脑海马的影响

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Oxidative stress may be regarded as an imbalance between free radical production and opposing antioxidant defenses. Free radical oxidative stress is implicated in rat cerebral ischemia and naturaceutical antioxidants are dietary supplements that have been reported to have neuroprotective activity. Many studies have reported dietary sesame oil (SO) as an effective antioxidant. In the present study the neuroprotective effect of dietary SO was evaluated against middle cerebral artery occlusion (MCAO)-induced cerebral ischemia injury in rats. Rats were fed on diet (20% SO) for 15 days. The middle cerebral artery of adult male Wistar rat was occluded for 2 h and reperfused for 22 h. The antioxidant properties of brain were measured as levels of reduced glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxide (GPx), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD) and thiobarbituric acid reactive substance (TBARS). A decrease in the activity of all the enzymatic and non-enzymatic antioxidants was observed along with an increase in lipid peroxidation (LPO) in MCAO group. The neurobehavioral activity of rats was also observed by using videopath analyzer. Dietary SO improved the antioxidant status in MCAO+SO group when compared with MCAO group. The results of neurobehavioral activity also support our biochemical data. The results obtained suggest protective effect of SO against cerebral ischemia in rat brain through their antioxidant properties. (c) 2006 Published by Elsevier Inc.
机译：氧化应激可被认为是自由基产生和相反的抗氧化防御之间的不平衡。自由基氧化应激与大鼠脑缺血有关，而天然抗氧化剂是据报道具有神经保护活性的膳食补充剂。许多研究已报告饮食中的芝麻油（SO）是有效的抗氧化剂。在本研究中，评估了饮食中的SO对大鼠中脑动脉闭塞（MCAO）引起的脑缺血损伤的神经保护作用。给大鼠喂食饮食（20％SO）15天。成年雄性Wistar大鼠的大脑中动脉闭塞2小时，再灌注22小时。测量大脑的抗氧化特性，包括还原型谷胱甘肽（GSH），谷胱甘肽S-转移酶（GST），谷胱甘肽过氧化物（GPx），谷胱甘肽还原酶（GR），过氧化氢酶（CAT），超氧化物歧化酶（SOD）和硫代巴比妥酸的水平反应性物质（TBARS）。 MCAO组中所有酶和非酶抗氧化剂的活性均降低，脂质过氧化（LPO）升高。还使用视频路径分析仪观察了大鼠的神经行为活性。与MCAO组相比，日粮SO改善了MCAO + SO组的抗氧化状态。神经行为活动的结果也支持我们的生化数据。获得的结果表明SO通过其抗氧化特性对大鼠脑缺血的保护作用。 （c）2006年由Elsevier Inc.发布。

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