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Regulation of glucose transport by thyroid hormone in rat ovary

机译：甲状腺激素对大鼠卵巢葡萄糖转运的调节

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Thyroid hormone (TH) plays an important role in regulating ovarian development. However, the mechanism involved remains unclear. Evidence suggests that glucose is essential for ovarian development, and its uptake is mediated by several glucose transporter proteins (Glut). We have investigated the effects of TH on Glut in rat ovary. Immature rats were treated with 6-propyl-2-thiouracil or L-thyroxine to induce hypothyroidism (hypo) or hyperthyroidism (hyper), respectively. Ovarian weights significantly decreased in both treated groups compared with the control group, although the body weights were not markedly altered. Glut1 expression significantly decreased without further changes being detected in the other Glut isforms in the hypo group and was accompanied by minimal change in mRNA content. The expression of Glut1 decreased in the hyper group. In contrast, L-thyroxine significantly increased Glut4 mRNA level and protein content but had little effect on Glut2 and Glut3 expression. Serum glucose concentrations in the hyper group were dramatically reduced compared with those in the control group. However, the serum glucose levels in the hypo group were not significantly changed. In addition, equine chorionic gonadotropin (eCG) increased ovarian weights in both the hypo and hyper groups compared with those in the rats without eCG injection. Glut2-4 protein content was significantly increased by eCG in hyper rats. Only the Glut4 mRNA content was significantly increased by eCG in the hyper group. Although the mRNA levels were not significantly changed by eCG in the hypo group, the protein level of Glut4 was markedly up-regulated. Serum glucose levels were not significantly altered by eCG in the two groups. Thus, dysfunction of the thyroid gland changes Glut expression in rat ovary and ovarian growth, both of which are also regulated by gonadotropin.
机译：甲状腺激素（TH）在调节卵巢发育中起重要作用。但是，所涉及的机制仍不清楚。有证据表明，葡萄糖对于卵巢发育至关重要，其摄取是由几种葡萄糖转运蛋白（Glut）介导的。我们已经研究了TH对大鼠卵巢Glut的影响。用6-丙基-2-硫尿嘧啶或L-甲状腺素治疗未成熟的大鼠，分别引起甲状腺功能减退（hypo甲状腺功能减退）或甲状腺功能亢进（过度）。尽管体重没有明显改变，但与对照组相比，两个治疗组的卵巢重量均显着降低。在hypo组的其他Glut亚型中，Glut1表达显着下降，而未检测到进一步的变化，并且伴随着最小的mRNA含量变化。高组中Glut1的表达降低。相反，L-甲状腺素显着增加Glut4 mRNA水平和蛋白质含量，但对Glut2和Glut3表达影响很小。与对照组相比，高组中的血清葡萄糖浓度显着降低。但是，低剂量组的血糖水平没有明显改变。此外，与未注射eCG的大鼠相比，低血脂和高血脂组马绒毛膜促性腺激素（eCG）增加了卵巢重量。 eCG在高大鼠中Glut2-4蛋白含量显着增加。高组中只有eG显着增加了Glut4 mRNA的含量。虽然在次品组中eCG的mRNA水平没有明显改变，但Glut4的蛋白水平却明显上调。两组中的eCG均未显着改变血清葡萄糖水平。因此，甲状腺功能异常会改变大鼠卵巢和卵巢生长中的Glut表达，这两者也都受到促性腺激素的调节。

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