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首页> 外文期刊>Cell and Tissue Research >A novel aspect of the structure of the avian thymic medulla
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A novel aspect of the structure of the avian thymic medulla

机译：禽胸腺髓质结构的新颖方面

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摘要

We provide evidence for the compartmentalization of the avian thymic medulla and identify the avian thymic dendritic cell. The thymic anlage develops from an epithelial cord of the branchial endoderm. Branches of the cord are separated by primary septae of neural crest origin. The dilation of the primary septae produces the keratin-negative area (KNA) of the thymic medulla and fills the gaps of the keratin-positive network (KPN). Morphometric analysis indicates that the KNA takes up about half of the volume of the thymic medulla, which has reticular connective tissue, like peripheral lymphoid organs. The KNA receives blood vessels and in addition to pericytes, the myoid cells of striated muscle structure occupy this area. The myoid cells are of branchial arch or prechordal plate origin providing indirect evidence for the neural crest origin of the KNA. The marginal epithelial cells of the KPN co-express keratin and vimentin intermediate filaments, which indicate their functional peculiarity. The basal lamina of the primary septum is discontinuous on the surface of the KPN providing histological evidence for the loss of the blood-thymus barrier in the medulla. In the center of the KNA, the dendritic cells lie in close association with blood vessels, whereas the B-cells accumulate along the KPN. The organization of the KPN and KNA increases the "surface" of the so-called cortico-medullary border, thereby contributing to the efficacy of central tolerance.
机译：我们为禽胸腺髓质的分隔提供了证据，并鉴定了禽胸腺树突状细胞。胸腺纤维从the皮的上皮索发展而来。脐带的分支由神经c起源的原隔隔开。初生隔膜的扩张会产生胸腺髓质的角蛋白阴性区域（KNA），并填充角蛋白阳性网络（KPN）的间隙。形态计量学分析表明，KNA占据了胸腺髓质的一半，胸腺髓质具有网状结缔组织，如外周淋巴器官。 KNA接收血管，除周细胞外，横纹肌结构的肌样细胞占据了该区域。肌样细胞起源于arch弓或脉前盘，为KNA的神经c起源提供了间接证据。 KPN的边缘上皮细胞共表达角蛋白和波形蛋白中间丝，表明它们的功能特殊性。主隔膜的基底层在KPN的表面上是不连续的，提供了髓质中血胸腺屏障丧失的组织学证据。在KNA的中央，树突状细胞与血管紧密相连，而B细胞则沿KPN积累。 KPN和KNA的组织增加了所谓的皮质-髓质边界的“表面”，从而有助于增强中央耐受性。

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