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2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic.

机译：2-脱氧葡萄糖：抗癌和抗病毒治疗剂，但不再是低糖模拟物。

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2-Deoxyglucose (2-DG), a non-metabolizable glucose analogue, blocks glycolysis and inhibits protein glycosylation. It has been tested in multiple studies for possible application as an anticancer or antiviral therapeutic. The inhibitory effect of 2-DG on ATP generation made it a good candidate molecule as a calorie restriction mimetic as well. Furthermore, 2-DG has been utilized in numerous studies to simulate a condition of glucose starvation. Because 2-DG disrupts glucose metabolism, protein glycosylation, and ER quality control at the same time, a cellular or pathologic outcome could be easily misinterpreted without clear understanding of 2-DG's effect on each of these aspects. However, the effect of 2-DG on protein glycosylation has rarely been investigated. A recent study suggested that 2-DG causes hyperGlcNAcylation of proteins, while low glucose supply causes hypoGlcNAcylation. In certain aspects of cellular physiology, this difference could be disregarded, but in others, this may possibly causetotally different outcomes.
机译：2-Deoxyglucose（2-DG），一种不可代谢的葡萄糖类似物，可阻止糖酵解并抑制蛋白质糖基化。它已在多项研究中进行了测试，可能用作抗癌药或抗病毒药。 2-DG对ATP产生的抑制作用使其也成为卡路里限制模拟物的良好候选分子。此外，2-DG已被用于许多研究中以模拟葡萄糖饥饿的状况。由于2-DG同时破坏葡萄糖代谢，蛋白质糖基化和ER质量控制，因此如果不明确了解2-DG在上述各个方面的作用，就很容易误解细胞或病理结果。但是，很少研究2-DG对蛋白质糖基化的影响。最近的一项研究表明2-DG导致蛋白质的hyperGlcNAcylation，而低葡萄糖供应会导致hypoGlcNAcylation。在细胞生理学的某些方面，可以忽略这种差异，但在其他方面，则可能导致完全不同的结果。

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