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首页> 外文期刊>Life sciences >beta 1 antagonist and beta 2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNF alpha in rat with type II diabetes
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beta 1 antagonist and beta 2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNF alpha in rat with type II diabetes

机译：β1拮抗剂和β2激动剂头孢洛尔在II型糖尿病大鼠中恢复受损的内皮依赖性和独立性应答并降低TNFα

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The effect of p antagonists in the diabetic vascular lesion is controversial. We investigated the effect of celiprolol hydrochloride, a P I antagonist and mild beta 2 agonist, on the lesions and function in type II male Otsuka Long-Evans Tokushima Fatty (OLETF) diabetic rats. OLETF rats were fed regular chow with or without atenolol (25 mg/kg/day) or celiprolol (100 mg/kg/day) treatment (group DM, no treatment; group DM-a, atenolol treatment; group DM-c, celiprolol treatment), and treatment was continued for 31 days. Separately, normoglycemic control rats, LETO, were prepared as group C. On day 3, endothelial cells of the right internal carotid artery were removed by balloon injury, and the rats were evaluated 4 weeks after balloon injury. The plasma glucose and lipid levels were unchanged throughout the treatment period. Intimal thickening was observed in the right carotid artery in the DM and DM-a groups; however, little thickening was observed in those of DM-c rats. Acetylcholine-induced NO-dependent relaxation in arteries was improved in DM-c rats compared with DM and DM-a rats (maximum relaxation DM 30.8 +/- 4.5, DM-a 37.4 +/- 3.9, DM-c 48.8 +/- 4.6%, *P < 0.05 vs. DM for DM-c rats). Tone-related basal NO release and acetylcholine-induced NO-dependent relaxation in the arteries and plasma NOx (sum of NO2- and NO3-) were greater in DM-c and C groups than in DM and TNF alpha groups. The serum TNF alpha levels did not increase in DM-c rats compared with those of the DM or DM-a groups, and were comparable with those of group C. Conclusion: In conclusion, Celiprolol improves endothelial function in the arteries of OLETF rats, and further restore it 4 weeks after endothelial denudation in the arteries of OLETF rats. NO and O-2(-) may have a role in the important underlying mechanisms by reducing the TNF alpha levels. (c) 2006 Elsevier Inc. All rights reserved.
机译：p拮抗剂在糖尿病性血管病变中的作用是有争议的。我们研究了II雄性大冢长埃文斯德岛肥胖（OLETF）糖尿病大鼠中盐酸匹立洛尔（一种P I拮抗剂和轻度β2激动剂）对皮损和功能的影响。 OLETF大鼠接受常规食物加或不加阿替洛尔（25 mg / kg /天）或西酞洛尔（100 mg / kg /天）治疗（DM组，未治疗; DM-a组，阿替洛尔治疗; DM-c组，celiprolol治疗），并持续治疗31天。单独地，将正常血糖对照组大鼠LETO作为C组。在第3天，通过球囊损伤去除右颈内动脉的内皮细胞，并且在球囊损伤后4周对大鼠进行评估。在整个治疗期间，血浆葡萄糖和脂质水平没有变化。 DM和DM-a组的右颈动脉内膜增厚。然而，在DM-c大鼠中几乎观察不到增厚。与DM和DM-a大鼠相比，DM-c大鼠的乙酰胆碱诱导的动脉NO依赖性舒张有所改善（最大舒张DM 30.8 +/- 4.5，DM-a 37.4 +/- 3.9，DM-c 48.8 +/- 4.6％，对于DM-c大鼠，* P <0.05 vs. DM）。与DM和TNFα组相比，DM-c和C组与动脉相关的基音NO释放和乙酰胆碱诱导的NO依赖性舒张（血浆NOx和NO3-的总和）更大。与DM或DM-a组相比，DM-c大鼠的血清TNFα水平没有增加，与C组相当。结论：总之，头孢洛尔可改善OLETF大鼠动脉的内皮功能，并在OLETF大鼠的动脉内皮剥脱后4周进一步恢复。 NO和O-2（-）可能通过降低TNFα水平而在重要的潜在机制中起作用。 （c）2006 Elsevier Inc.保留所有权利。

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