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首页> 外文期刊>Life sciences >Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts.
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Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts.

机译：EGCg或绿茶儿茶素差向异构体GCg对豚鼠心脏缺血后心肌功能障碍的保护作用。

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摘要

The protective effects of (-)-epigallocatechin-3-gallate (EGCg) or the C-2 epimer, (-)-gallocatechin-3-gallate (GCg), afforded by their antioxidative activity among green tea catechins were investigated in perfused guinea-pig Langendorff hearts subjected to ischemia and reperfusion. The recovery (%) of the left ventricular developed pressure from ischemia by reperfusion was 34.4% in the control, while in the presence of EGCg (3x10(-5) M) or GCg (3x10(-6) M, a more diluted concentration than that of EGCg), it led to a maximal increase of 78.4% or 76.2%, consistent with a significant preservative effect on the tissue level of ATP at the end of ischemia or reperfusion. In the perfused preparation of mitochondria, EGCg (10(-5) M) inhibited mitochondrial Ca(2+) elevation by changes in the Ca(2+) content or the acidification of perfusate, similarly to findings with cyclosporin A, a well known inhibitor of the mitochondrial permeability transition pore. By in vitro electron paramagnetic resonance (EPR), EGCg or GCg was found to directly quench the activity of active oxygen radicals, with the strongest activity in tea catechins. EGCg or GCg decreased the caspase-3 activity induced apoptosis. Therefore, it is concluded that the beneficial effects of EGCg or GCg play an important role in ischemia-reperfusion hearts in close relation with nitric oxide (NO), active oxygen radicals and biological redox systems in mitochondria.
机译：在灌注的几内亚中研究了（-）-表没食子儿茶素3-没食子酸酯（EGCg）或C-2差向异构体（-）-没食子儿茶素-3-没食子酸酯（GCg）在绿茶儿茶素中的保护作用。 -猪Langendorff心脏遭受缺血和再灌注。在对照组中，通过再灌注从局部缺血中左心室发育压力的恢复（％）为34.4％，而在存在更稀释的EGCg（3x10（-5）M）或GCg（3x10（-6）M）的情况下与EGCg相比）最高增加了78.4％或76.2％，这与缺血或再灌注结束时对ATP组织水平的显着防腐作用一致。在灌注的线粒体制备中，EGCg（10（-5）M）通过改变Ca（2+）含量或酸化灌注液来抑制线粒体Ca（2+）升高，这与环孢菌素A的发现类似线粒体通透性过渡孔抑制剂。通过体外电子顺磁共振（EPR），发现EGCg或GCg可直接淬灭活性氧自由基的活性，在茶儿茶素中具有最强的活性。 EGCg或GCg降低了caspase-3活性诱导的细胞凋亡。因此，可以得出结论，EGCg或GCg的有益作用在缺血再灌注心脏中起重要作用，与一氧化氮（NO），活性氧自由基和线粒体中的生物氧化还原系统密切相关。

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