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Quantitative microscopy of mole rat eosinophil granule morphology

机译：鼠痣嗜酸性粒细胞形态的定量显微镜观察

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摘要

Mole rat bone marrow cells and peritoneal eosinophils are used to study granule morphological maturation by quantitative microscopy. The bulk eosinophil granule content is pre-stored in unique granular structures known as crystalloid or secondary granules. Mole rat eosinophil granules exhibit the basic structure of an electron-dense crystalloid core surrounded by a lighter, homogeneous matrix. Morphometric analysis demonstrated that bone marrow-derived eosinophil sphere-like granules display a periodic, multimodal granule volume distribution. In contrast, peritoneal eosinophils display cigar-shaped granules, whose crystalloid cores are more variable in size and shape as compared to bone marrow eosinophil granules. Using a morphometric approach, we deduced that the basic granule volume quantum is similar in both cases, suggesting that the sphere-like young eosinophil granules turn into dense ellipsoidal ones by intragranular processes in which both volume and membrane surface are conserved. Crystalloid granule mediators are known to be widely associated with allergic inflammatory events, which may damage the host tissue following secretion to the extracellular environment. Based on mathematical modeling, we suggest that this deviation from sphere-like to ellipsoidal shape reflects an adaptive response of the mole rat to its unique solitary life.
机译：quantitative鼠骨髓细胞和腹膜嗜酸性粒细胞用于通过定量显微镜研究颗粒形态成熟。嗜酸性粒细胞的大部分成分被预先存储在称为晶体或次级颗粒的独特颗粒结构中。痣鼠嗜酸性粒细胞颗粒显示出被较轻的均质基质包围的电子致密晶体核的基本结构。形态分析表明，骨髓来源的嗜酸性粒细胞球形颗粒表现出周期性的多峰颗粒体积分布。相反，腹膜嗜酸性粒细胞表现出雪茄状的颗粒，与骨髓嗜酸性粒细胞颗粒相比，其晶体核的大小和形状更加可变。使用形态计量学方法，我们推断两种情况下的基本颗粒体积量子相似，这表明球形的嗜酸性粒细胞颗粒通过颗粒内过程变成密实的椭圆形颗粒，其中体积和膜表面均被保留。已知晶体颗粒介质与过敏性炎症事件广泛相关，在分泌到细胞外环境后可能会损害宿主组织。基于数学模型，我们建议从球形到椭圆形的这种偏离反映出the鼠对其独特的孤独生活的适应性反应。

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