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首页> 外文期刊>Cell and Tissue Research >Early down-regulation of milk production after weaning by pup removal and prior to involution in mouse mammary glands
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Early down-regulation of milk production after weaning by pup removal and prior to involution in mouse mammary glands

机译：断奶后断奶后和小鼠乳腺消融之前，牛奶产量的早期下调

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The mammary gland is a highly specialized organ that is able to repeat development and regression (involution) of alveolar structures for milk production. Mammary involution consists in two phases. The first phase is reversible and lasts until approximately 48 h after weaning in mice. Interestingly, an extended milking interval can change the milk-secretory activity of alveolar epithelial cells (AECs) before the first phase of involution begins. In this study, we investigate the changes in the ability of AECs to secrete milk during the involution progression. Careful observation of the number and locations of cleaved caspase-3 positive AECs revealed that the first phase of involution occurred approximately 24 h after weaning and the second phase began between 48 and 72 h after weaning. However, initial changes in the milk production ability of AECs began just 1 h after weaning and milk production gradually ceased within 24 h. In addition, activation of STAT3 and inactivation of STAT5 had occurred in some AECs by 6 h after weaning and more broadly by 24 h. In addition, milk production processes such as nutrient uptake, synthesis, and secretion ceased by 24 h post-weaning. Interestingly, enlarged cytoplasmic lipid droplets were observed in AECs 12 h after weaning even though the expression levels of genes relevant to triglyceride production (Srebp1 and AQP3) were down-regulated. These results indicate that several changes in the milk production ability of AECs occur during expanded suckling intervals and prior to involution.
机译：乳腺是一种高度专业化的器官，能够重复进行牙槽结构的发育和消退（对合）以生产牛奶。乳腺退化包括两个阶段。第一阶段是可逆的，持续至小鼠断奶后约48小时。有趣的是，延长的挤奶间隔可以改变内卷的第一个阶段开始之前的肺泡上皮细胞（AEC）的乳汁分泌活性。在这项研究中，我们调查了进化过程中AEC分泌乳汁的能力的变化。仔细观察裂解的caspase-3阳性AEC的数量和位置可以发现，对合的第一阶段发生在断奶后约24小时，第二阶段开始于断奶后48至72小时。但是，断奶后1小时，AEC的产奶能力开始发生初步变化，并且在24小时内逐渐停止产奶。另外，在断奶后6小时，某些AEC中发生了STAT3的激活和STAT5的失活，更广泛的是在24h。此外，断奶后24小时停止了牛奶的生产过程，例如营养吸收，合成和分泌。有趣的是，即使断奶后甘油三酸酯产生相关基因（Srebp1和AQP3）的表达水平下调，在断奶后12 h的AEC中也观察到了较大的胞质脂质滴。这些结果表明，在扩大的哺乳间隔期间和内卷之前，AEC的产奶能力发生了一些变化。

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