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首页> 外文期刊>Cell and Tissue Research >Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile
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Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile

机译：Hox和ParaHox基因在海鞘幼体中沿消化道的有序表达模式

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摘要

The Hox and ParaHox genes of bilateria share a similar expression pattern along the body axis and are known to be associated with anterior-posterior patterning. In vertebrates, the Hox genes are also expressed in presomitic mesoderm and gut endoderm and the ParaHox genes show a restricted expression pattern in the gut-related derivatives. Regional expression patterns in the embryonic central nervous system of the basal chordates amphioxus and ascidian have been reported; however, little is known about their endodermal expression in the alimentary canal. We focus on the Hox and ParaHox genes in the ascidian Ciona intestinalis and investigate the gene expression patterns in the juvenile, which shows morphological regionality in the alimentary canal. Gene expression analyses by using whole-mount in situ hybridization reveal that all Hox genes have a regional expression pattern along the alimentary canal. Expression of Hox1 to Hox4 is restricted to the posterior region of pharyngeal derivatives. Hox5 to Hox13 show an ordered expression pattern correlated with each Hox gene number along the postpharyngeal digestive tract. This expression pattern along the anterior-posterior axis has also been observed in Ciona ParaHox genes. Our observations suggest that ascidian Hox and ParaHox clusters are dispersed; however, the ordered expression patterns along the alimentary canal appear to be conserved among chordates.
机译：Bilateria的Hox和ParaHox基因沿体轴共享相似的表达模式，并且已知与前后模式相关。在脊椎动物中，Hox基因也在早熟中胚层和肠道内胚层中表达，ParaHox基因在肠道相关衍生物中显示出受限的表达模式。据报道，两栖和双足基脉的胚胎中枢神经系统中有区域性表达模式。然而，人们对它们在消化道中的内胚层表达知之甚少。我们专注于海鞘Ciona intestinalis中的Hox和ParaHox基因，并研究了少年中的基因表达模式，显示了消化道的形态区域性。通过全量原位杂交进行的基因表达分析表明，所有Hox基因在消化道上均具有区域表达模式。 Hox1到Hox4的表达仅限于咽衍生物的后部区域。 Hox5至Hox13显示与沿着咽后消化道的每个Hox基因编号相关的有序表达模式。在Ciona ParaHox基因中也观察到了沿前后轴的这种表达方式。我们的观察结果表明，海底Hox和ParaHox团簇分散;然而，沿着食道的有序表达方式在脊索动物中似乎是保守的。

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