• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Inhibitory action of spinorphin, an endogenous regulator of enkephalin-degrading enzymes, on carrageenan-induced polymorphonuclear neutrophil accumulation in mouse air-pouches.
【24h】

Inhibitory action of spinorphin, an endogenous regulator of enkephalin-degrading enzymes, on carrageenan-induced polymorphonuclear neutrophil accumulation in mouse air-pouches.

机译：Spinorphin（一种脑啡肽降解酶的内源性调节剂）对角叉菜胶诱导的小鼠气袋中多形核嗜中性粒细胞积累的抑制作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Whether spinorphin, an endogenous regulator of enkephalin-degrading enzymes, plays a role in an anti-inflammatory action was examined, using a mouse air-pouch assay as a model of acute inflammation. Repeated intravenous administration (6 times) of spinorphin every hour significantly suppressed carrageenan-induced polymorphonuclear neutrophil (PMN) accumulation, an indicator of inflammation (3.21+/-0.95 x 10[6] cells vs 8.92+/-0.96 x 10[6] cells, 10mg/kg spinorphin-treated vs saline-treated group, n=5, P<0.01) at 6 hr. The combination of spinorphin and leuhistin (2 mg/kg, i.v.), a specific inhibitor of aminopeptidase N (APN), markedly suppressed the PMN accumulation induced by carrageenan (1.11+/-0.17 x 10[6] cells, 88% inhibition compared to the saline-treated group, n=5, P<0.01). This inhibition was less than, but comparable to that of dexamethasone (30 mg/kg/one shot, i. v.), a representative anti-inflammatory drug. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator, its inhibitory activity being modulated by APN.
机译：使用小鼠气袋试验作为急性炎症模型，检查了脑啡肽降解酶的内源性调节剂斯诺福啡是否在抗炎作用中起作用。每小时重复静脉内注射（6次）Spinorphin可显着抑制角叉菜胶诱导的多形核中性粒细胞（PMN）积累，这是炎症的指标（3.21 +/- 0.95 x 10 [6]细胞vs 8.92 +/- 0.96 x 10 [6]在6小时时，分别用10mg / kg的Spinorphin处理组和生理盐水处理组，n = 5，P <0.01）。氨基肽酶N（APN）的特异抑制剂Spinorphin和leuhistin（2 mg / kg，iv）的组合可显着抑制角叉菜胶诱导的PMN积聚（1.11 +/- 0.17 x 10 [6]细胞，相比抑制率88％盐水治疗组，n = 5，P <0.01）。这种抑制作用小于但可与代表性的抗炎药地塞米松（30 mg / kg /次，静脉注射）相比。这些结果表明，菠菜啡可能是内源性抗炎调节剂，其抑制活性受APN调节。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号