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首页> 外文期刊>Life sciences >Involvement of high density lipoprotein as substrate cholesterol for steroidogenesis by bovine adrenal fasciculo-reticularis cells.
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Involvement of high density lipoprotein as substrate cholesterol for steroidogenesis by bovine adrenal fasciculo-reticularis cells.

机译：高密度脂蛋白作为牛肾上腺筋膜网状细胞类固醇生成的底物胆固醇参与。

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摘要

Adrenocorticosteroids are known to be synthesized from cholesterol which may arise from de novo synthesis or from the uptake of low-density lipoproteins (LDL) or high-density lipoproteins (HDL). LDL is reported to be a main substrate for corticosteroid synthesis by bovine adrenocortical cells, although the role of HDL, which is well known to be used for steroid biosynthesis in rat adrenals, is still obscure. Therefore, we examined the role of HDL in the regulation of corticosteroidogenesis in bovine adrenals in order to clarify whether or not HDL was selectively utilized for corticosteroid synthesis in vitro. The present data demonstrated that HDL and LDL increased cortisol production in a dose-dependent manner in bovine adrenocortical cells in vitro, and also that HDL cholesterol increased cortisol production significantly higher than LDL cholesterol did. Addition of adrenocorticotrophic hormone (ACTH) with HDL to the incubation media enhanced much higher cortisol production than that with LDL in short time incubation. The present data also demonstrated that uptake of 125I-HDL was significantly greater than that of 125I-LDL. Thus, HDL rather than LDL is thought to be the preferred lipoprotein as a source of steroidogenic substrate cholesterol in bovine adrenal fasciculo-reticularis cells.
机译：已知肾上腺皮质类固醇是由胆固醇合成的，胆固醇可能是从头合成或摄取低密度脂蛋白（LDL）或高密度脂蛋白（HDL）引起的。据报导，LDL是牛肾上腺皮质细胞合成皮质类固醇的主要底物，尽管HDL（众所周知用于大鼠肾上腺类固醇生物合成）的作用仍然不清楚。因此，我们研究了HDL在调节牛肾上腺皮质类固醇生成中的作用，以阐明HDL是否在体外选择性地用于皮质类固醇合成。目前的数据表明，HDL和LDL在体外在牛肾上腺皮质细胞中以剂量依赖的方式增加了皮质醇的产生，而且HDL胆固醇增加的皮质醇的产生显着高于LDL胆固醇。在短时间孵育中，将HDL添加到肾上腺皮质营养激素（ACTH）会比使用LDL促肾上腺皮质营养激素（ACTH）产生的皮质醇产量高得多。本数据还表明125I-HDL的摄取显着大于125I-LDL。因此，HDL而不是LDL被认为是优选的脂蛋白，作为牛肾上腺筋膜-网状细胞中类固醇生成底物胆固醇的来源。

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