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Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency

机译：锌缺乏促进社交孤立诱导的幼鼠攻击行为

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Neuropsychological behavior via activation of the hypothalamic-pituitary-adrenal (HPA) axis was analyzed using young mice fed a zinc-deficient diet for 2 weeks. Serum corticosterone concentration was significantly increased after 2-week zinc deprivation, whereas zinc concentration in the brain was not decreased. In the resident-intruder test, the rate of mice that exhibited aggressive behavior to the total mice was significantly higher in isolated zinc-deficient mice than in isolated control mice. The duration of aggressive behavior was more in isolated zinc-deficient mice. These results indicate that aggressive behavior of young mice elicited by social isolation is enhanced by zinc deficiency. On the other hand, social isolation-induced aggressive behavior was enhanced in isolated pair-fed mice with food restriction that can activate the HPA axis. Serum corticosterone concentration was also significantly higher in isolated zinc-deficient mice. To see the effect of the increased serum corticosterone on behavioral abnormality, neurotransmitter concentrations in brain tissue were checked. The concentrations of glutamate and GABA in brain tissue were significantly higher in both grouped and isolated zinc-deficient mice. Furthermore, the concentration of extracellular glutamate in the amygdala before the resident-intruder test was significantly higher in isolated zinc-deficient (aggressive) mice and the higher concentration was maintained during the test. The changes in neurotransmitter homeostasis, probably via the increase in serum corticosterone, seem to be linked to aggressive behavior elicited by social isolation in zinc deficiency. (c) 2008 Elsevier Inc. All rights reserved.
机译：使用饲喂缺锌饮食2周的小老鼠分析了通过激活下丘脑-垂体-肾上腺（HPA）轴的神经心理行为。缺锌2周后，血清皮质酮浓度显着增加，而脑中锌浓度未降低。在常驻入侵者测试中，在孤立的缺锌小鼠中，表现出攻击行为的小鼠对总小鼠的发生率明显高于孤立的对照小鼠。在孤立的缺锌小鼠中，攻击行为的持续时间更长。这些结果表明，锌缺乏会增强社交隔离引起的年轻小鼠的攻击行为。另一方面，在孤立的成对喂养的老鼠中，受食物限制的可激活HPA轴的行为增强了社会隔离引起的攻击行为。隔离的锌缺乏小鼠的血清皮质酮浓度也显着较高。为了观察血清皮质酮水平升高对行为异常的影响，检查了脑组织中神经递质的浓度。在分组和分离的缺锌小鼠中，脑组织中谷氨酸和GABA的浓度均显着较高。此外，在常驻入侵者测试之前，杏仁体中胞外谷氨酸的浓度在隔离的锌缺乏（攻击性）小鼠中明显更高，并且在测试过程中保持较高的浓度。神经递质稳态的变化，可能是由于血清皮质酮的增加，似乎与锌缺乏的社会隔离引起的攻击性行为有关。 （c）2008 Elsevier Inc.保留所有权利。

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