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首页> 外文期刊>Life sciences >Hypothalamic-pituitary-adrenal axis activity in the inbred Brown Norway and Fischer 344 rat strains.
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Hypothalamic-pituitary-adrenal axis activity in the inbred Brown Norway and Fischer 344 rat strains.

机译：自交系Brown Norway和Fischer 344大鼠品系的下丘脑-垂体-肾上腺轴活性。

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摘要

We have examined the basal and the stress-induced secretion of corticosterone in relation to the expression of adrenal steroid receptors in the pituitary, hypothalamus and hippocampus of the inbred Brown Norway and Fischer 344 rat strains. Our data indicated that plasma transcortin and integrated plasma corticosterone levels were significantly higher in Fischer 344 compared to Brown Norway rats. Fischer 344 hypersecrete corticosterone during the dark phase of the diurnal cycle and during the phase of recovery following a 20 min period of restraint stress compared to Brown Norway rats. This hypersecretion of corticosterone was negatively correlated with the size of the adrenal gland but might be related to the higher density of mineralocorticoid receptors in the hippocampus of Fischer 344 rats.
机译：我们检查了近交布朗挪威和费舍尔344大鼠品系的垂体，下丘脑和海马中肾上腺类固醇受体表达与皮质激素的基础分泌和应激诱导分泌有关。我们的数据表明，与棕色挪威大鼠相比，Fischer 344中的血浆跨皮质素和整合血浆皮质酮水平明显更高。与布朗挪威大鼠相比，Fischer 344皮质激素超分泌在昼夜周期的黑暗阶段以及在20分钟的束缚压力后的恢复阶段。皮质酮的这种过度分泌与肾上腺的大小负相关，但可能与Fischer 344大鼠海马中盐皮质激素受体的更高密度有关。

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