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首页> 外文期刊>Life sciences >Evidence of non-synaptic regulation of postpartum uterine contractility in the rat.
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Evidence of non-synaptic regulation of postpartum uterine contractility in the rat.

机译：在大鼠中非突触调节产后子宫收缩的证据。

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摘要

Myometrial tissue rings from postpartum rats (24 h after delivery) were studied in vitro by electric field stimulation, and the alpha1/beta2-adrenoceptor ratio was determined by a radioligand binding technique. Pregnancy-denervated uterine rings were stimulated by long-duration pulses (100 ms). The contractions were inhibited by beta2-agonists (terbutaline and fenoterol) and alpha-antagonists (phentolamine, urapidil and yohimbine) in a concentration-dependent manner. Their effects were not altered by the adrenergic neuron-blocking agent bretylium. The alpha-antagonists (except phentolamine) elicited the same maximal inhibition as the beta2-agonists. Receptor assays revealed that the alpha1/beta2 ratio was about 2 in the measured uteri. It was concluded that the inhibitory effects of alpha-antagonists and beta2-agonists are mediated via non-synaptic adrenoceptors of the denervated postpartum rat uterus. The same inhibitory activity could be explained by the greater amount of alpha-receptors. It is believed that this is the first functional proof of the existence of non-synaptic alpha1-adrenoceptors in smooth muscle.
机译：通过电场刺激体外研究了产后大鼠（分娩后24 h）的子宫肌层组织环，并通过放射性配体结合技术确定了α1/β2-肾上腺素受体的比率。持续时间较长的脉冲（100毫秒）刺激了去妊娠的子宫环。 β2激动剂（特布他林和非诺特罗）和α拮抗剂（苯妥拉明，乌拉地尔和育亨宾）以浓度依赖性方式抑制收缩。肾上腺素能神经元阻滞剂bretylium不会改变它们的作用。 α-拮抗剂（苯妥拉明除外）引起的最大抑制作用与β2-激动剂相同。受体测定表明，在被测子宫中，α1/β2的比例约为2。结论是，α-拮抗剂和β2-激动剂的抑制作用是通过失神经的产后大鼠子宫的非突触肾上腺素受体介导的。相同的抑制活性可以通过大量的α受体来解释。据信这是平滑肌中非突触α1-肾上腺素受体存在的第一个功能证明。

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