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首页> 外文期刊>Life sciences >Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord.
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Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord.

机译：Endomorphin-2，deltorphin II及其类似物抑制大鼠脊髓中福尔马林诱导的伤害感受和c-Fos表达。

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In this study, we evaluated the effects of intrathecally administered agonists of mu- and delta-opioid receptor and their analogs on the pain-induced behavior and expression of c-Fos immunoreactivity in the spinal cord, elicited by intraplantar injection of 12% formalin to the hindpaw of the rat. Previous report from our laboratory and other author's study indicated that intrathecal administration of mu agonists morphine and endomorphin-2 and delta-opioid agonist deltorphin II produced a dose-dependent antinociceptive effects in acute and inflammatory pain. In this study, intrathecal injection of morphine (10 microg), endomorphin-2 (5 microg) and its analog Dmt-endomorphin-2 (10 microg) significantly decreased the formalin-induced pain behavior, and lowered a number of c-Fos positive neurons in the laminae I, II and III of the spinal cord by about 40%, 30% and 40%, respectively. Significant reduction of formalin-induced behavioral responses was also observed after i.th. administration of deltorphin II (15 microg) and its analog ile-deltorphin II (15 microg). Agonists of delta-opioid receptor significantly reduced a number of c-Fos positive neurons by about 28% and 40%, respectively. Analog of endomorphin-2 and analog of deltorphin II suppressed more potently expression of c-Fos in the dorsal horn of the spinal cord than the parent peptides. Our study indicates that new analogs of mu- and delta-opioid receptor exhibit strong antinociceptive potency similar or even higher than the parent peptides, and that their effect is positively correlated with the inhibition of c-Fos expression.
机译：在这项研究中，我们评估了鞘内注射mu和delta类阿片受体激动剂及其类似物对疼痛诱导的行为和脊髓内c-Fos免疫反应性表达的影响，该作用是通过足底注射12％福尔马林引起的。老鼠的后爪。我们实验室和其他作者研究的先前报告指出，鞘内注射mu激动剂吗啡和endomorphin-2和δ阿片类激动剂deltorphin II在急性和炎性疼痛中产生剂量依赖性的镇痛作用。在这项研究中，鞘内注射吗啡（10微克），内啡肽2（5微克）及其类似物Dmt-内啡肽2（10微克）显着降低了福尔马林引起的疼痛行为，并降低了c-Fos阳性脊髓的层I，II和III中的神经元分别减少了约40％，30％和40％。 i.th.之后也观察到福尔马林诱导的行为反应的显着降低。服用deltorphin II（15微克）及其类似物ile-deltorphin II（15微克）。 δ阿片受体激动剂分别使大量c-Fos阳性神经元分别减少了约28％和40％。与母体肽相比，endomorphin-2的类似物和deltorphin II的类似物更有效地抑制了脊髓背角中c-Fos的表达。我们的研究表明，μ-阿片受体和δ-阿片受体的新类似物表现出强大的抗伤害感受力，甚至高于亲本肽，而且它们的作用与c-Fos表达的抑制呈正相关。

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