• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats.
【24h】

Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats.

机译：褪黑素对大鼠海马切片癫痫活动的昼夜作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Since melatonin receptors have been found in the hippocampus of mammals it has been suggested that melatonin can modulate neuronal functions of hippocampal cells. The effect of melatonin (10 nM/l and 1 microM/l) on frequency and amplitude of epileptiform field potentials (EFP) elicited by low Mg(2+) or by bicuculline was tested in the CA1 region of hippocampal slices of rats. In the low Mg(2+) model, melatonin, applied in a near physiological concentration of 10 nM/l, exerts no effect on EFP in slices prepared at night or during the day. In a concentration of 1 microM/l, however, melatonin enhances the frequency of EFP to approximately 140% in slices prepared during the day. This effect was suppressed through simultaneous administration of the melatonin receptor antagonist luzindole (10 microM/l). In contrast, melatonin did not affect epileptic activity in slices prepared at night. Epileptiform discharges elicited by blocking the GABAergic inhibition (bicuculline model) were not affected by melatonin, either during the day or at night. The results indicate that melatonin affects epileptic activity in a diurnal manner and that the action of melatonin is different in relation to the epilepsy model.
机译：由于已经在哺乳动物的海马体中发现了褪黑激素受体，因此已经提出褪黑激素可以调节海马细胞的神经元功能。在大鼠海马切片的CA1区测试了褪黑激素（10 nM / l和1 microM / l）对低Mg（2+）或双小分子引起的癫痫样场电位（EFP）频率和振幅的影响。在低Mg（2+）模型中，褪黑激素以接近10 nM / l的生理浓度应用，对夜间或白天制备的切片中的EFP无效。但是，褪黑激素浓度为1 microM / l时，可使白天制备的切片中EFP的频率增加至约140％。通过同时给予褪黑激素受体拮抗剂鲁辛多（10 microM / l）抑制了该作用。相反，褪黑激素并不影响夜间准备的切片的癫痫活性。阻断GABA能抑制引起的癫痫样放电（双核模型）在白天或晚上都不受褪黑激素的影响。结果表明，褪黑激素以昼夜方式影响癫痫活动，并且褪黑激素的作用与癫痫模型有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号