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LONG-TERM EFFECTS OF INHALED NICOTINE

机译：吸入烟碱的长期作用

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Tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation. [References: 29]
机译：据报道，吸烟与心血管疾病和癌症，尤其是肺部疾病的风险增加有关。尽管对吸烟对健康的影响进行了广泛的研究，但烟草烟中具有这些负面健康影响的物质尚不完全清楚。尼古丁是赋予主观吸烟和诱发成瘾的物质。我们首次报告长期（两年）吸入尼古丁对大鼠的影响。大鼠在尼古丁的房间内呼吸，其浓度为重度吸烟者的血浆浓度的两倍。在两年期间，每周五天，每天20小时给予尼古丁。与对照组相比，这些大鼠的死亡率，动脉粥样硬化或肿瘤发生率均未增加。特别地，没有微观或宏观的肺肿瘤，并且肺神经内分泌细胞没有任何增加。然而，在整个研究中，与对照组相比，暴露于尼古丁的大鼠的体重降低了。总而言之，我们的研究没有表明以纯净形式吸入时尼古丁有任何有害作用。 [参考：29]

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