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首页> 外文期刊>Life sciences >EFFECT OF CHRONIC COCAINE EXPOSURE ON CAROTID ARTERY REACTIVITY IN NEONATAL RABBITS
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EFFECT OF CHRONIC COCAINE EXPOSURE ON CAROTID ARTERY REACTIVITY IN NEONATAL RABBITS

机译：慢性可卡因暴露对新生兔颈动脉反应性的影响

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Chronic cocaine abuse by pregnant women results in chronic neonatal drug exposure. In adults, chronic cocaine use alters neurotransmitter concentrations and receptor dose-response relationships. Similar changes may also occur in the neonatal cerebrovasculature after in utero cocaine exposure. This study examined the effect of chronic cocaine exposure on internal carotid artery reactivity to norepinephrine, serotonin, acetylcholine, sodium nitroprusside, adenosine, and cocaine in neonatal rabbits. Internal carotid artery rings were isolated from 16 to 20 day old rabbits that had received cocaine (20 mg/kg IP BID, n=8) or saline (n=8) from 5 days of age and were studied in organ baths using standard in vitro techniques. Chronic treatment with cocaine decreased the half-maximal relaxant response (ED(50)) to adenosine (control 6.9 +/- 1.8 vs cocaine 3.5 +/- 0.99 mu M, p=.05). The half-maximal contractile responses (EC(50)) to norepinephrine and serotonin and the half-maximal relaxant responses (ED(50)) to acetylcholine and sodium nitroprusside were similar between groups. The threshhold concentration of cocaine that induced vessel contraction was altered by chronic cocaine exposure (control group 10(-6) M vs chronic cocaine group 10(-4) M). We conclude that chronic cocaine exposure sensitizes carotid arteries to the relaxant effects of adenosine. In addition, chronic cocaine exposure desensitizes carotid arteries to the contractile effects of acute cocaine. These vasoreactivity changes may underlie altered cerebrovascular responses to asphyxia and play a role in the pathogenesis of postnatally acquired brain injury in critically ill ''crack'' babies. [References: 38]
机译：孕妇长期滥用可卡因会导致慢性新生儿药物暴露。在成年人中，长期使用可卡因会改变神经递质的浓度和受体的剂量反应关系。宫内可卡因暴露后，新生儿脑血管系统也可能发生类似变化。这项研究检查了慢性可卡因暴露对新生兔颈动脉对去甲肾上腺素，血清素，乙酰胆碱，硝普钠，腺苷和可卡因反应性的影响。从16日龄至20日龄的兔子中分离颈内动脉环，这些兔子从5天龄开始接受可卡因（20 mg / kg IP BID，n = 8）或生理盐水（n = 8），并在器官浴中使用标准的方法研究。体外技术。长期用可卡因治疗可降低对腺苷的半数最大松弛反应（ED（50））（对照组6.9 +/- 1.8与可卡因3.5 +/- 0.99μM，p = .05）。两组之间对去甲肾上腺素和5-羟色胺的最大收缩反应（EC（50））以及对乙酰胆碱和硝普钠的最大松弛反应（ED（50））的一半相似。慢性可卡因暴露可改变诱导血管收缩的可卡因阈值浓度（对照组10（-6）M与慢性可卡因组10（-4）M）。我们得出的结论是，可卡因的长期暴露可使颈动脉对腺苷的松弛作用敏感。此外，慢性可卡因暴露会使颈动脉对急性可卡因的收缩作用不敏感。这些血管反应性改变可能是脑血管对窒息反应改变的基础，并在重症“高危”婴儿出生后获得性脑损伤的发病机理中发挥作用。 [参考：38]

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