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首页> 外文期刊>Life sciences >Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocylokines in fructose-induced insulin resistant hamsters
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Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocylokines in fructose-induced insulin resistant hamsters

机译：柑橘多甲氧基黄酮可改善果糖诱导的胰岛素抵抗性仓鼠的脂质和葡萄糖稳态，并调节脂肪细胞因子

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摘要

The present study was undertaken to determine whether supplementation with polymethoxylated flavones (PMFs) could ameliorate the fructose-induced hypertriglyceridemia and other metabolic abnormalities associated with insulin resistance (IR) in hamsters. Following feeding with the fructose diet, hamsters were supplemented orally with PMF-L or PMF-H (62.5 and 125 mg/kg/day) for 4 weeks. Both PMF-treated groups showed a statistically significant (p < 0.05) decrease in serum triglyceride (TG) and cholesterol levels compared to the fructose-fed control group. The fructose control group at the end of the study showed elevated serum insulin and impaired insulin sensitivity (glucose intolerance). On the other hand, PMF-supplemented groups showed a reversal in these metabolic defects, including a decrease in insulin level and an improvement in glucose tolerance. PMF supplementation also reduced TG contents in the liver and heart and was able to regulate adipocytokines by significantly suppressing TNF-alpha, INF-gamma, IL-1 beta and IL-6 expression and increasing adiponectin in IR hamsters. The mechanism of PMF on the activation of peroxisome proliferator-activated receptors (PPAR) was also explored. PMF-H supplementation significantly increased PPAR alpha and PPAR gamma protein expression in the liver. This is the first report of positive effects of PMF on adipocytokine production and on PPAR expression in IR hamsters. This study suggests that PMF can ameliorate hypertriglyceridemia and its anti-diabetic effects may occur as a consequence of adipocytokine regulation and PPAR alpha and PPAR gamma activation. (c) 2006 Elsevier Inc. All rights reserved.
机译：进行本研究，以确定补充聚甲氧基黄酮（PMFs）是否可以减轻果糖诱导的高甘油三酯血症和仓鼠中与胰岛素抵抗（IR）相关的其他代谢异常。用果糖饮食喂养后，给仓鼠口服PMF-L或PMF-H（62.5和125 mg / kg /天），持续4周。与果糖喂养的对照组相比，两个PMF治疗组的血清甘油三酸酯（TG）和胆固醇水平均有统计学显着性降低（p <0.05）。研究结束时的果糖对照组显示血清胰岛素升高和胰岛素敏感性受损（葡萄糖耐受不良）。另一方面，补充PMF的组显示出这些代谢缺陷的逆转，包括胰岛素水平的下降和葡萄糖耐量的改善。补充PMF还可以降低肝脏和心脏中的TG含量，并且能够通过显着抑制TNF-α，INF-γ，IL-1β和IL-6的表达并增加IR仓鼠的脂联素来调节脂肪细胞因子。还探讨了PMF对过氧化物酶体增殖物激活受体（PPAR）激活的机制。补充PMF-H会显着增加肝脏中PPARα和PPARγ蛋白的表达。这是PMF对IR仓鼠中脂肪细胞因子产生和PPAR表达产生积极影响的第一个报道。这项研究表明，PMF可以减轻高甘油三酯血症，其抗糖尿病作用可能是由于脂肪细胞因子调节以及PPARα和PPARγ激活而产生的。 （c）2006 Elsevier Inc.保留所有权利。

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