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Nicotine's attenuation of body weight involves the perifornical hypothalamus

机译：尼古丁引起的体重减轻涉及下丘脑下丘脑

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Previously we showed that intermittent administration of nicotine (NIC) in the dark phase decreased food intake and body weight and this could be blocked when the NIC receptor antagonist mecamylamine was infused into the fourth ventricle. Catecholaminergic neurons adjacent to the fourth ventricle contain NIC receptors and directly innervate the perifornical hypothalamus (PFH) which has been shown to be involved in regulation of feeding. This study explored whether NIC regulates feeding behavior by modulating catecholaminergic input to the PFH. Epinephrine and norepinephrine neuronal input was ablated within the PFH by infusion of 6-hydroxydopamine hydrobromide (6-OHDA), while bupropion was infused to protect dopaminergic neurons. After recovery of body weights to pre-surgery levels, food intake, meal size, meal number and body weight were measured after intermittent NIC injections. The results showed the PFH lesioned animals did not exhibit the typical prolonged drop in food intake, meal size and body weight normally associated with NIC administration. High performance liquid chromatography analyses demonstrated that compared to control rats, 6-OHDA administration significantly reduced PFH norepinephrine and epinephrine levels, but not dopamine levels. These results are consistent with NIC reducing food intake in part by acting through catecholaminergic neurons within or extending through the PFH. (c) 2007 Elsevier Inc. All rights reserved.
机译：以前，我们证明了在黑暗阶段间歇给药尼古丁（NIC）会减少食物摄入和体重，当将NIC受体拮抗剂美卡明胺注入第四脑室时，这可以被阻止。邻近第四脑室的儿茶酚胺能神经元含有NIC受体，直接神经支配下进食的下丘脑下丘脑（PFH）。本研究探讨了NIC是否通过调节对PFH的儿茶酚胺能输入来调节喂养行为。输注6-羟基多巴胺氢溴酸盐（6-OHDA）消融了PFH中的肾上腺素和去甲肾上腺素神经元输入，同时注入了安非他酮以保护多巴胺能神经元。体重恢复到术前水平后，在间歇性NIC注射后测量进食量，进餐量，进餐量和体重。结果表明，PFH病变的动物通常与NIC施用相关的食物摄入，进食量和体重并未出现典型的长时间下降。高效液相色谱分析表明，与对照组相比，使用6-OHDA可以显着降低PFH去甲肾上腺素和肾上腺素的水平，但不能降低多巴胺的水平。这些结果与NIC通过在PFH内或通过PFH延伸通过儿茶酚胺能神经元起作用而部分减少食物摄入量是一致的。 （c）2007 Elsevier Inc.保留所有权利。

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