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首页> 外文期刊>Life sciences >The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury
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The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury

机译：异osteviol对心脏缺血再灌注损伤大鼠的心脏保护作用

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This study was designed to assess the cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion (IR) injury and to explore the mechanism of action of the compound. Sprague Dawley rats were divided into 8 groups (n = 10-12): a sham-operated control and 7 ischemia-reperfusion groups (IR control, 3 isosteviol pre-treated (0.5, 1.0 and 2.0 mg kg(-1)), ligustrazine pre-treated, 5-hydroxydecanoate (5-HD) pretreated and 5-HD+ isosteviol pre-treated groups). IR was produced by occluding the left coronary artery for 30 min followed by re-opening the artery for 90 min. The compounds under investigation were administered intravenously 10 min prior to occluding the artery. Hemodynamic parameters ( +/- dp/dt(max), LVSP, LVDevP, MAP), heart rate, ventricular tachycardia (VT) and ventricular fibrillation (VF) were determined during the IR period. The myocardial infarct size, activities of serum lactate dehydrogenase and creatine kinase were determined at the end of the experiment. In the isosteviol pre-treated groups, the hemodynamic parameters were improved and the myocardial infarct size, the activities of serum enzymes, and the incidences of VT and VF were all decreased when compared to the control group. These effects of isosteviol were similar to that of a traditional cardioprotective agent, ligustrazine. The 5-HD+ isosteviol group displayed parameters that were between those in the equivalent isosteviol pre-treated group and the IR control group. In conclusion, damage due to a standard rat heart IR injury was reduced by pretreatment with intravenous isosteviol, and this effect was partly attenuated by a mitochondrial ATP-sensitive potassium channel blocker, 5-HD. (c) 2006 Elsevier Inc. All rights reserved.
机译：这项研究旨在评估异甾醇对心脏缺血再灌注（IR）损伤大鼠的心脏保护作用，并探讨该化合物的作用机理。将Sprague Dawley大鼠分为8组（n = 10-12）：假手术对照组和7个缺血再灌注组（IR对照，3个异黄酮醇预处理（0.5、1.0和2.0 mg kg（-1））），川gust嗪预处理，5-羟基癸酸酯（5-HD）预处理和5-HD +异osteviol预处理组）。通过闭塞左冠状动脉30分钟，然后重新打开动脉90分钟来产生IR。被研究的化合物在阻塞动脉前10分钟静脉内给药。在IR期间确定血流动力学参数（+/- dp / dt（max），LVSP，LVDevP，MAP），心率，室性心动过速（VT）和室颤（VF）。实验结束时测定心肌梗塞面积，血清乳酸脱氢酶和肌酸激酶活性。与对照组相比，异osteviol预处理组的血液动力学参数得到改善，心肌梗死面积，血清酶活性以及VT和VF的发生率均降低。异osteviol的这些作用类似于传统的心脏保护剂川gust嗪。 5-HD +异戊烯醇组显示的参数介于同等异戊醇预处理组和IR对照组之间。总之，通过静脉注射异麦芽酚进行预处理，可以减轻标准的大鼠心脏IR损伤所引起的损害，而线粒体ATP敏感性钾通道阻滞剂5-HD可以部分削弱这种作用。 （c）2006 Elsevier Inc.保留所有权利。

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