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首页> 外文期刊>Life sciences >Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.
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Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.

机译：慢性乙醇摄入后神经病大鼠脊髓NMDA受体NR2B亚基功能的变化。

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Chronic ethanol consumption produces painful neuropathy for which there is no reliably successful therapy, largely due to a lack of understanding of the central mechanisms that underlie the development of the neuropathic pain-like state induced by chronic ethanol treatment. The aim of this study was to investigate what mechanisms contribute to the neuropathic pain-like state induced by chronic ethanol treatment in rats. Mechanical hyperalgesia was clearly observed during ethanol consumption and even after ethanol withdrawal, and lasted for 14 weeks. This hyperalgesia was significantly attenuated by repeated i.p. injection of ifenprodil, a selective NR2B subunit-containing NMDA receptor antagonist. Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats. Interestingly, phosphorylated-Ser-1303 NR2B (p-Ser1303-NR2B) subunit was significantly increased in the spinal cord of chronic ethanol-fed rats, whereas p-Tyr1472-NR2B was not affected in the superficial spinal dorsal horn of ethanol-fed rats. These findings suggest that spinal p-Ser1303-NR2B plays a significant role in the development of the ethanol-dependent neuropathic pain-like state in rats.
机译：长期服用乙醇会产生痛苦的神经病，目前尚无可靠的成功疗法，这在很大程度上是由于缺乏对慢性乙醇治疗诱发的神经性疼痛样状态发展的主要机制的了解。这项研究的目的是研究由慢性乙醇治疗诱发大鼠神经性疼痛样状态的机制。在摄入乙醇期间甚至撤出乙醇后均明显观察到机械性痛觉过敏，持续了14周。重复腹膜内注射可明显减轻这种痛觉过敏。注射ifenprodil，一种选择性的含有NR2B亚基的NMDA受体拮抗剂。在这些条件下，慢性乙醇喂养大鼠的脊髓中NR1，NR2A和NR2B亚基的mRNA和蛋白水平没有变化。有趣的是，慢性乙醇喂养大鼠的脊髓中磷酸化的Ser-1303 NR2B（p-Ser1303-NR2B）亚基显着增加，而乙醇喂养大鼠的浅表脊髓背角中p-Tyr1472-NR2B并未受到影响。这些发现表明，脊髓p-Ser1303-NR2B在大鼠乙醇依赖性神经性疼痛样状态的发展中起重要作用。

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