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首页> 外文期刊>Life sciences >Towards mimicking natural protein channels with aligned carbon nanotube membranes for active drug delivery.
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Towards mimicking natural protein channels with aligned carbon nanotube membranes for active drug delivery.

机译：试图通过对齐的碳纳米管膜模仿天然蛋白通道，以实现主动药物递送。

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AIMS: Carbon nanotube (CNT) membranes offer an exciting opportunity to mimic natural protein channels due to 1) a mechanism of dramatically enhanced fluid flow 2) ability to place 'gatekeeper' chemistry at the entrance to pores 3) the ability for biochemical reactions to occur on gatekeeper molecules and 4) an ability to chemically functionalize each side of the membrane independently. MAIN METHODS: Aligned CNT membranes were fabricated and CNT pore entrances modified with gatekeeper chemistry. Pressure driven fluid flow and diffusion experiments were performed to study the mechanisms of transport through CNTs. KEY FINDINGS: The transport mechanism through CNT membranes is primarily 1) ionic diffusion near bulk expectation 2) gas flow enhanced 1-2 orders of magnitude primarily due to specular reflection 3) fluid flow 4-5 orders of magnitude faster than conventional materials due to a nearly ideal slip-boundary interface. The transport can be modulated by 'gatekeeper' chemistry at the pore entrance using steric hindrance, electrostatic attraction/repulsion, or biochemical state. The conformation of charged tethered molecules can be modulated by applied bias setting the stage for programmable drug release devices. SIGNIFICANCE: The membrane structure is mechanically far more robust than lipid bilayer films, allowing for large-scale chemical separations, delivery or sensing based on the principles of protein channels. The performance of protein channels is several orders of magnitude faster than conventional membrane materials. The fundamental requirements of mimicking protein channels are present in the CNT membrane system.
机译：目的：碳纳米管（CNT）膜为模拟天然蛋白质通道提供了令人兴奋的机会，这是因为1）显着增强流体流动的机制2）将“守门人”化学物质置于孔的入口处的能力3）生化反应的能力出现在看门者分子上，并且4）具有独立化学功能化膜两侧的能力。主要方法：制备对齐的CNT膜，并用Gatekeeper化学方法修饰CNT孔入口。进行了压力驱动的流体流动和扩散实验，以研究通过碳纳米管传输的机理。主要发现：穿过CNT膜的传输机制主要是1）接近大体积预期的离子扩散2）主要由于镜面反射，气体流量增加了1-2个数量级3）由于以下原因，流体的流动速度比常规材料快4-5个数量级几乎理想的滑移边界界面。可以通过使用空间位阻，静电吸引/排斥或生化状态的孔入口处的“关守”化学来调节运输。带电的束缚分子的构象可以通过施加偏压来调节，从而为可编程药物释放装置设定阶段。重要性：膜结构在机械上比脂质双层膜坚固得多，可以根据蛋白质通道的原理进行大规模的化学分离，递送或传感。蛋白质通道的性能比常规膜材料快几个数量级。 CNT膜系统中存在模拟蛋白质通道的基本要求。

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