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首页> 外文期刊>Life sciences >The possible involvement of dopamine D3 receptors in the regulation of gastric emptying in rats.
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The possible involvement of dopamine D3 receptors in the regulation of gastric emptying in rats.

机译：多巴胺D3受体可能参与了大鼠胃排空的调节。

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AIM: The inhibitory effect of dopamine on gastric motility is thought to be mediated via a decrease in acetylcholine release resulting from stimulation of enteric neuronal dopamine D(2) receptors. The aim of this study was to investigate the possible involvement of the dopamine D(3) receptor in the regulation of gastric motility in rats using selective dopamine D(3) receptor agonists or a dopamine D(3) receptor antagonist. MAIN METHODS: Gastric emptying was assessed using the phenol red method after rats were treated with varying doses of dopamine D(3) receptor agonists or a dopamine D(3) receptor antagonist. KEY FINDINGS: S(+)-PD 128,907 (0.01-1 mg/kg, s.c.), a selective dopamine D(3) receptor agonist, dose-dependently delayed gastric emptying in rats. Other dopamine D(3) receptor agonists (i.e., R(+)-7-OH-DPAT [0.03-1 mg/kg, s.c.] and quinpirole [0.01-1 mg/kg, s.c.]) also delayed gastric emptying in rats. Both the selective dopamine D(1) and D(5) receptor agonist SKF-38393 and the selective dopamine D(4) receptor agonist PD 168,077 failed to delay gastric emptying in rats. The selective dopamine D(3) receptor antagonist (+)-S 14297 (10mg/kg, s.c.) partially inhibited the S(+)-PD 128,907-induced delay in gastric emptying. Although an administration of S(+)-PD 128,907 (1-100 mug/kg) into the 4th cerebral ventricle partially and dose-dependently delayed gastric emptying in rats, its administration into the lateral cerebral ventricle did not affect gastric emptying. SIGNIFICANCE: The results presented here suggest that peripheral dopamine D(2) receptors and, at least in part, dopamine D(3) and central dopamine D(2)/D(3) receptors play an important role in the regulation of gastric motility in rats.
机译：目的：多巴胺对胃动力的抑制作用被认为是由于肠神经元多巴胺D（2）受体刺激引起的乙酰胆碱释放减少所介导的。这项研究的目的是调查使用选择性多巴胺D（3）受体激动剂或多巴胺D（3）受体拮抗剂在大鼠胃动力调节中可能涉及多巴胺D（3）受体。主要方法：用不同剂量的多巴胺D（3）受体激动剂或多巴胺D（3）受体拮抗剂治疗大鼠后，用酚红法评估胃排空情况。主要发现：S（+）-PD 128,907（0.01-1 mg / kg，s.c.），一种选择性的多巴胺D（3）受体激动剂，剂量依赖性地延迟了大鼠的胃排空。其他多巴胺D（3）受体激动剂（即R（+）-7-OH-DPAT [0.03-1 mg / kg，sc]和喹吡罗[0.01-1 mg / kg，sc]）也延迟了大鼠的胃排空。选择性多巴胺D（1）和D（5）受体激动剂SKF-38393和选择性多巴胺D（4）受体激动剂PD 168,077均未能延迟大鼠胃排空。选择性多巴胺D（3）受体拮抗剂（+）-S 14297（10mg / kg，s.c.）部分抑制S（+）-PD 128,907诱导的胃排空延迟。尽管将S（+）-PD 128,907（1-100 mug / kg）局部和剂量依赖性地延迟了大鼠的胃排空，但向大鼠侧脑室的给药并未影响胃排空。意义：此处显示的结果表明外周多巴胺D（2）受体，以及至少部分多巴胺D（3）和中央多巴胺D（2）/ D（3）受体在胃动力调节中起重要作用在大鼠中。

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