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Evaluation of toluene dependence and cross-sensitization to diazepam.

机译：评估甲苯依赖性和对地西epa的交叉敏化。

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摘要

Acute effects of the abused inhalant toluene resemble those of CNS depressant drugs. Since abuse of toluene involves repeated use, the purpose of the present study was to evaluate the effects of repeated or continuous exposure to toluene and to compare these effects to those of other inhalants and depressants. In experiment 1, ICR mice exposed continuously to 250 ppm toluene via inhalation for four days developed mild dependence upon termination that was characterized by an increase in severity of handling-induced convulsions. However, administration of the convulsants, N-methyl-D-aspartate (NMDA) or pentylenetetrazole (PTZ), did not differentially affect toluene- vs. air-exposed mice. In experiment 2, CFW mice (but not ICR mice) developed cross-sensitization to the initial locomotor stimulatory effects of toluene following four days of injections with 10 mg/kg/day diazepam. Previous findings have shown that 1,1,1-trichloroethane (TCE) produced robust dependence and cross-sensitization to diazepam's locomotor effects when tested under similar conditions. The present results suggest that the dependence and cross-sensitization with diazepam produced by toluene are milder than those induced by TCE. Further, these studies add to increasing evidence that abused inhalants do not have identical pharmacological effects.
机译：滥用的吸入甲苯的急性作用类似于中枢神经系统抑制药。由于甲苯的滥用涉及重复使用，因此本研究的目的是评估反复或连续暴露于甲苯的影响，并将这些影响与其他吸入剂和镇静剂进行比较。在实验1中，通过吸入连续四天连续暴露于250 ppm甲苯的ICR小鼠表现出对终止的轻度依赖性，其特征是处理引起的惊厥严重程度增加。但是，服用惊厥剂N-甲基-D-天门冬氨酸（NMDA）或戊四氮（PTZ）并不会影响甲苯和空气暴露的小鼠。在实验2中，CFW小鼠（而非ICR小鼠）在注射10 mg / kg /天地西epa后四天对甲苯的初始运动刺激作用产生了交叉致敏作用。先前的发现表明，在类似条件下进行测试时，1,1,1-三氯乙烷（TCE）对地西epa的运动作用产生强依赖性和交叉敏感性。目前的结果表明甲苯产生的地西epa的依赖性和交叉敏化作用比TCE诱导的依赖性和交叉敏化作用轻。此外，这些研究增加了越来越多的证据表明滥用的吸入剂不具有相同的药理作用。

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