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首页> 外文期刊>Cell biology international. >The molecular stoichiometric hydration model (SHM) as applied to tendon/collagen, globular proteins and cells.
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The molecular stoichiometric hydration model (SHM) as applied to tendon/collagen, globular proteins and cells.

机译：分子化学计量水合模型（SHM）适用于肌腱/胶原蛋白，球状蛋白质和细胞。

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This report describes and documents the presence of multiple water-of-hydration fractions on proteins and in cells. Initial studies of hydration fractions in g of water/g of DM (dry mass) for tendon/collagen led to the development of the molecular SHM (stoichiometric hydration model) and the development of methods for calculating the size of hydration fractions on a number of different proteins of known amino acid composition. The water fractions have differences in molecular motion and other physical properties due to electrostatic interactions of polar water molecules with electric fields generated by covalently bound pairs of opposite partial charge on the protein backbone. The methods allow calculation of the size of four hydration fractions: single water bridges, double water bridges, dielectric water clusters over polar-hydrophilic surfaces and water clusters over hydrophobic surfaces. These four fractions provide monolayer water coverage. The predicted SHM hydration fractions match closely measured hydration fraction values for collagen and for globular proteins. This report also presents water sorption findings that support the SHM. The SHM is applicable for cell systems where it has been studied. In seven cell systems studied, more than half of all of the cell water had properties unlike those of bulk water. The SHM predicts and explains the commonly cited and measured bound water fraction of 0.2-0.4 g of water/g of DM on proteins. The commonly accepted concept that water beyond this bound water fraction can be considered bulk-like water in its physical properties is unwarranted.
机译：该报告描述并记录了蛋白质和细胞中存在多个水合馏分。最初对肌腱/胶原蛋白中以g水/ g DM（干物质）为单位的水合分数的研究导致了分子SHM（化学计量水合模型）的发展，以及许多计算水合分数大小的方法的发展。已知氨基酸组成的不同蛋白质。由于极性水分子与蛋白质骨架上相反部分电荷的共价结合对产生的电场之间的静电相互作用，水馏分在分子运动和其他物理性质上具有差异。该方法允许计算四个水合部分的大小：单水桥，双水桥，极性亲水表面上的介电水团簇和疏水表面上的水团簇。这四个部分提供单层水覆盖。预测的SHM水合分数与胶原蛋白和球状蛋白的水合分数紧密匹配。该报告还提出了支持SHM的水吸收发现。 SHM适用于已经研究过的电池系统。在研究的七个电池系统中，所有电池水的一半以上具有与散装水不同的特性。 SHM预测并解释了蛋白质中通常引用和测量的0.2-0.4 g水/ g DM结合水分数。人们普遍认为，超出此束缚水含量的水在其物理性质上可以视为大块状水，这一点是不必要的。

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