• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables.
【24h】

Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables.

机译：无毒的花青素是水果和蔬菜中的色素，可抑制人体肿瘤细胞的生长。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Anthocyanidins, the aglycones of anthocyanins, impart brilliant colors in many fruits and vegetables. The widespread consumption of diets rich in anthocyanin and anthocyanidins prompted us to determine their inhibitory effects on human cancer cell proliferation. Five anthocyanidins, cyanidin (1), delphinidin (2), pelargonidin (3), petunidin (4) and malvidin (5), and four anthocyanins, cyanidin-3-glucoside, cyanidin-3-galactoside, delphinidin-3-galactoside and pelargonidin-3-galactoside were tested for cell proliferation inhibitory activity against human cancer cell lines, AGS (stomach), HCT-116 (colon), MCF-7 (breast), NCI H460 (lung), and SF-268 (Central Nervous System, CNS) at 12.5-200 microg/mL concentrations. The viability of cells after exposure to anthocyanins and anthocyanidins was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) colorimetric methods. The anthocyanins assayed did not inhibit cell proliferation of cell lines tested at 200 microg/mL. However, anthocyanidins showed cell proliferation inhibitory activity. Malvidin inhibited AGS, HCT-116, NCI-H460, MCF-7 and SF-268 cell growth by 69, 75.7, 67.7, 74.7 and 40.5%, respectively, at 200 microg/mL. Similarly, pelargonidin inhibited AGS, HCT-116, NCI H460, MCF-7 and SF-268 cell growth by 64, 63, 62, 63 and 34%, respectively, at 200 microg/mL. At 200 microg/mL, cyanidin, delphinidin and petunidin inhibited the breast cancer cell growth by 47, 66 and 53%, respectively. This is the first report of tumor cell proliferation inhibitory activity by anthocyanidins.
机译：花青素，花青素的糖苷配基，赋予许多水果和蔬菜鲜艳的色彩。富含花青素和花青素的饮食的广泛消费促使我们确定它们对人类癌细胞增殖的抑制作用。五种花色苷，花青素（1），翠雀素（2），pelargonidin（3），petunidin（4）和Malvidin（5）和四种花色苷，花青素-3-葡糖苷，花青素-3-半乳糖苷，delphinidin-3-半乳糖苷和测试了pelargonidin-3-galactoside对人癌细胞，AGS（胃），HCT-116（结肠），MCF-7（乳腺），NCI H460（肺）和SF-268（中枢神经细胞）的细胞增殖抑制活性系统（CNS），浓度为12.5-200 microg / mL。通过MTT（3- [4,5-二甲基噻唑-2-基] -2,5-二苯基四唑溴化物）比色法确定暴露于花青素和花青素后的细胞活力。测定的花色苷不抑制以200微克/毫升测试的细胞系的细胞增殖。然而，花青素显示出细胞增殖抑制活性。 Malvidin在200 microg / mL时分别抑制AGS，HCT-116，NCI-H460，MCF-7和SF-268细胞生长69、75.7、67.7、74.7和40.5％。同样，pelargonidin在200 microg / mL时分别抑制AGS，HCT-116，NCI H460，MCF-7和SF-268细胞生长64、63、62、63和34％。在200微克/毫升下，花青素，翠雀素和矮牵牛苷分别抑制乳腺癌细胞的生长47％，66％和53％。这是花色苷对肿瘤细胞增殖抑制活性的首次报道。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号