• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats.
【24h】

Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats.

机译：大鼠海马内注射β-淀粉样蛋白1-40和卵磷脂的神经化学和行为学作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study was designed to investigate the effects of the intrahippocampal co-injection of beta-amyloid protein1-40 (Abeta(1-40)) with ibotenic acid (Ibo) on learning and memory in normal and aging model rats, and to explore the mechanism underlying the effects of the co-injection. The normal and aging rats were bilaterally injected Abeta(1-40) (4 microg for each side) with Ibo (2 microg for each side) into the hippocampus. Two weeks after the intrahippocampal injection, the exploratory behavior and learning-memory ability of the rats were tested by using open field, Y-maze and passive avoidance task. And the changes of membrane fluidity in hippocampal mitochondria, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in hippocampus were also examined. The co-injection of Abeta(1-40) with Ibo induced tested rats a remarkable decrease in the explorative behaviors and a significant decline in learning-memory ability (P < 0.01). The neurochemical changes induced by the co-injection included a significant decrease in membrane fluidity of hippocampal mitochondria (P < 0.01), a significant decrease in the activity of SOD (P < 0.01), as well as a remarkable increase in the content of MDA (P < 0.01). The results suggest that co-injection of Abeta(1-40) with Ibo may induce an increase of hippocampal damage by peroxidation and a serious deficit in the learning and memory of the rats. The results also suggest that the co-injection of Abeta(1-40) with Ibo may provide a useful animal model for the Alzheimer's disease (AD) research.
机译：本研究旨在研究在正常和衰老模型大鼠中海马内注射β-淀粉样蛋白1-40（Abeta（1-40））和卵磷脂（Ibo）对学习和记忆的影响，并探索共注入效应的潜在机制。正常和衰老大鼠向海马双侧注射Abeta（1-40）（每侧4微克）和Ibo（每侧2微克）。海马注射后两周，采用开阔视野，Y型迷宫和被动回避任务测试大鼠的探索行为和学习记忆能力。并检测了海马线粒体膜流动性，海马超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量的变化。 Abeta（1-40）与Ibo诱导的被测大鼠共注射时，其探索行为显着下降，学习记忆能力显着下降（P <0.01）。共注射引起的神经化学变化包括海马线粒体膜流动性显着降低（P <0.01），SOD活性显着降低（P <0.01）以及MDA含量显着增加（P <0.01）。结果表明，与Ibo共同注射Abeta（1-40）可能会导致过氧化引起的海马损伤增加，并严重损害大鼠的学习和记忆能力。结果还表明，Abeta（1-40）与Ibo的共同注射可能为阿尔茨海默氏病（AD）研究提供有用的动物模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号