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首页> 外文期刊>Life sciences >Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings.
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Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings.

机译：普伐他汀，阿托伐他汀和西立伐他汀对离体大鼠主动脉环的松弛作用。

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摘要

Increasing evidence suggests that statins may have pleiotropic effects on vascular wall independent of their cholesterol lowering properties. In the present study, we investigated the acute vascular effects of pravastatin, atorvastatin and cerivastatin on rat isolated aortic rings. Statins effectively and comparably relaxed the aortic rings precontracted submaximally with noradrenaline, in a concentration-dependent manner, in which a high potency was observed with cerivastatin. Endothelium removal or incubation of the aortic rings with nitric oxide synthase inhibitor L-NOARG (10(-4) M) and/or cyclooxygenase inhibitor indomethacin (10(-5) M) significantly attenuated the acute vasorelaxation induced by either of statin. Additionally, different from the other two statins, a significant reduction was observed in response to cerivastatin in the presence of KATP channel inhibitor, glibenclamide (10(-5) M) and Na+- K+ ATPase inhibitor, ouabain (10(-4) M). Furthermore, pretreatment of the rings with the cholesterol precursor mevalonate (10(-3) M) significantly inhibited the endothelium-mediated relaxant effects of the statins. Our findings suggest that statins could acutely modulate vascular tone importantly by endothelium-dependent and mevalonate-related pathways.
机译：越来越多的证据表明，他汀类药物可能对血管壁具有多效性，而与它们的胆固醇降低特性无关。在本研究中，我们调查了普伐他汀，阿托伐他汀和西立伐他汀对大鼠离体主动脉环的急性血管作用。他汀类药物以浓度依赖的方式有效而可比较地放松了与去甲肾上腺素预先最大程度收缩的主动脉环，其中西立伐他汀具有很高的效力。内皮细胞的去除或与一氧化氮合酶抑制剂L-NOARG（10（-4）M）和/或环氧合酶抑制剂吲哚美辛（10（-5）M）的主动脉环孵育显着减弱了两种他汀类药物引起的急性血管舒张。此外，与其他两种他汀类药物不同，在存在KATP通道抑制剂格列本脲（10（-5）M）和Na +-K + ATPase抑制剂哇巴因（10（-4）M的情况下，观察到对西立伐他汀的反应显着降低）。此外，用胆固醇前体甲羟戊酸酯（10（-3）M）预处理环显着抑制了他汀类药物的内皮介导的松弛作用。我们的发现表明，他汀类药物可以通过内皮依赖性和甲羟戊酸相关的途径来重要地急性调节血管紧张度。

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