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首页> 外文期刊>Life sciences >Different sensitivity of PPARalpha gene expression to nutritional changes in liver of suckling and adult rats.
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Different sensitivity of PPARalpha gene expression to nutritional changes in liver of suckling and adult rats.

机译：PPARalpha基因表达对乳鼠和成年大鼠肝脏营养变化的不同敏感性。

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摘要

The amount of peroxisome proliferator-activated receptor-alpha (PPARalpha) protein was markedly augmented in the liver of suckling rats compared to adult rats. This different PPARalpha abundance was used to study the sensitivity to nutritional changes in the expression and activity of this receptor. Thus, 10-day-old and adult rats were orally given either glucose, Intralipid or a combination of both diets, and liver mRNA levels of PPARalpha and the PPAR related genes, acyl-CoA oxidase (ACO) and phosphoenolpyruvate carboxykinase (PEPCK), and plasma metabolites were measured. In neonates, the expression of PPARalpha and ACO was seen to increase when the level of FFA in plasma was also high, unless an elevated level of insulin was also present. However, this fatty acid-induced effect was not detected in adult rats. On the contrary, the hepatic expression of PEPCK was modulated by the nutritional changes similarly in both neonates and adult rats. Thus, it may be concluded that the expression of the PPARalpha gene in adult rats seems to be less sensitive to nutritional changes than in neonates.
机译：与成年大鼠相比，乳鼠肝脏中的过氧化物酶体增殖物激活受体-α（PPARalpha）蛋白的量明显增加。这种不同的PPARalpha丰度用于研究该受体表达和活性对营养变化的敏感性。因此，给10日龄和成年大鼠口服葡萄糖，内脂或两种饮食的组合，以及PPARalpha和PPAR相关基因，酰基辅酶A氧化酶（ACO）和磷酸烯醇式丙酮酸羧激酶（PEPCK）的肝脏mRNA水平，并测定血浆代谢产物。在新生儿中，当血浆中FFA的水平也很高时，除非存在胰岛素水平的升高，否则PPARalpha和ACO的表达会增加。但是，在成年大鼠中未检测到这种脂肪酸诱导的作用。相反，在新生大鼠和成年大鼠中，PEPCK的肝表达受到营养变化的调节。因此，可以得出结论，成年大鼠中PPARalpha基因的表达似乎对营养的敏感性不如新生儿。

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