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首页> 外文期刊>Life sciences >Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.
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Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.

机译：阻燃剂四溴双酚A和相关化合物的抗甲状腺激素活性：与哺乳动物甲状腺激素受体的亲和力，并且对t变态有影响。

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摘要

The thyroid hormone-disrupting activity of tetrabromobisphenol A (TBBPA), a flame retardant, and related compounds was examined. TBBPA, tetrachlorobisphenol A (TCBPA), tetramethylbisphenol A (TMBPA) and 3,3'-dimethylbisphenol A (DMBPA) markedly inhibited the binding of triiodothyronine (T3; 1 x 10(-10) M) to thyroid hormone receptor in the concentration range of 1 x 10(-7)-1 x 10(-4) M, while bisphenol A and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA and DMBPA did not exhibit thyroid hormonal activity in a thyroid hormone-responsive reporter assay using a Chinese hamster ovary cell line (CHO-K1) transfected with thyroid hormone receptor alpha1 or beta1, but TBBPA and TCBPA showed significant anti-thyroid hormone effects on the activity of T3 (1 x 10(-8) M) in the concentration range of 3 x 10(-6) - 5 x 10(-5) M. The thyroid hormone-disrupting activity of TBBPA was also examined in terms of the effect on amphibian metamorphosis stimulated by thyroid hormone. TBBPA in the concentration range of 1 x 10(-8) to 1 x 10(-6) M showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening. These facts suggest that TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents.
机译：研究了阻燃剂四溴双酚A（TBBPA）和相关化合物的甲状腺激素破坏活性。在浓度范围内，TBBPA，四氯双酚A（TCBPA），四甲基双酚A（TMBPA）和3,3'-二甲基双酚A（DMBPA）显着抑制三碘甲状腺素（T3; 1 x 10（-10）M）与甲状腺激素受体的结合1 x 10（-7）-1 x 10（-4）M，而双酚A和2,2-二苯基丙烷则没有活性。使用转染了甲状腺激素受体α1或β1的中国仓鼠卵巢细胞系（CHO-K1），在甲状腺激素反应性报告基因测定中，TBBPA，TCBPA，TMBPA和DMBPA没有显示甲状腺激素活性，但是TBBPA和TCBPA显示出显着的抗在3 x 10（-6）-5 x 10（-5）M的浓度范围内，甲状腺激素对T3（1 x 10（-8）M）活性的影响。TBBPA的甲状腺激素破坏活性也是就甲状腺激素对两栖动物变态的影响进行了研究。 TBBPA在1 x 10（-8）到1 x 10（-6）M的浓度范围内显示了对毛蛙T3（5 x 10（-8）M）增强的抑制作用。这些事实表明，TBBPA，TCBPA，TMBPA和DMBPA可以起到破坏甲状腺激素的作用。

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