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Tocotrienols: Vitamin E beyond tocopherols.

机译：生育三烯酚：生育酚以外的维生素E。

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In nature, eight substances have been found to have vitamin E activity: alpha-, beta-, gamma- and delta-tocopherol; and alpha-, beta-, gamma- and delta-tocotrienol. Yet, of all papers on vitamin E listed in PubMed less than 1% relate to tocotrienols. The abundance of alpha-tocopherol in the human body and the comparable efficiency of all vitamin E molecules as antioxidants, led biologists to neglect the non-tocopherol vitamin E molecules as topics for basic and clinical research. Recent developments warrant a serious reconsideration of this conventional wisdom. Tocotrienols possess powerful neuroprotective, anti-cancer and cholesterol lowering properties that are often not exhibited by tocopherols. Current developments in vitamin E research clearly indicate that members of the vitamin E family are not redundant with respect to their biological functions. alpha-Tocotrienol, gamma-tocopherol, and delta-tocotrienol have emerged as vitamin E molecules with functions in health and disease that are clearly distinct from that of alpha-tocopherol. At nanomolar concentration, alpha-tocotrienol, not alpha-tocopherol, prevents neurodegeneration. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. An expanding body of evidence support that members of the vitamin E family are functionally unique. In recognition of this fact, title claims in manuscripts should be limited to the specific form of vitamin E studied. For example, evidence for toxicity of a specific form of tocopherol in excess may not be used to conclude that high-dosage vitamin E conclusion incorrectly implies that tocotrienols are toxic as well under conditions where tocotrienols were not even considered. The current state of knowledge warrants strategic investment into the lesser known forms of vitamin E. This will enable prudent selection of the appropriate vitamin E molecule for studies addressing a specific need.
机译：在自然界中，发现八种具有维生素E活性的物质：α-，β-，γ-和δ-生育酚;以及α-，β-，γ-和δ-生育三烯酚。然而，在PubMed中列出的有关维生素E的所有论文中，不到1％与生育三烯酚有关。人体中丰富的α-生育酚和所有维生素E分子作为抗氧化剂的可比效率，导致生物学家们忽略了非生育酚维生素E分子作为基础和临床研究的主题。最近的事态发展值得认真地重新考虑这种传统观念。生育三烯酚具有强大的神经保护，抗癌和降低胆固醇的特性，而生育酚通常不具备这种特性。维生素E研究的最新进展清楚地表明，维生素E家族的成员在生物学功能方面并非多余。 α-生育三烯酚，γ-生育酚和δ-生育三烯酚已经作为维生素E分子出现，在健康和疾病中的功能与α-生育酚明显不同。在纳摩尔浓度下，α-生育三烯酚而不是α-生育酚可防止神经变性。以浓度为基础，这一发现代表了任何天然维生素E分子所表现出的所有生物学功能中最有效的。越来越多的证据表明，维生素E家族的成员在功能上是独一无二的。认识到这一事实，手稿中的标题声明应限于所研究的维生素E的特定形式。例如，某种特定形式的生育酚的毒性过大的证据可能不能用来推断高剂量维生素E结论错误地暗示了生育三烯酚在甚至不考虑生育三烯酚的条件下也具有毒性。当前的知识状况需要对鲜为人知的维生素E进行战略投资。这将使我们可以谨慎地选择合适的维生素E分子用于研究特定需求。

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