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首页> 外文期刊>Life sciences >Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complex
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Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complex

机译：番荔枝番荔枝叶中己烷提取物在两种焦虑范式中的抗焦虑作用：GABA /苯并二氮杂receptor受体复合物的可能参与

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摘要

A hexane extract of leaves of Annona cherimolia produced anxiolytic-like actions when administered to mice and tested in two animal models of anxiety: the mouse avoidance exploratory behavior and the burying behavior tests. In order to discard unspecific drug-actions on general activity, all treatments studied in the anxiety paradigms were also analyzed in the open field test. Results showed that A. cherimolia induced anxiolytic-like actions at the doses of 6.25, 12.5, 25.0 and 50.0 mg/kg. Picrotoxin (0.25 mg/kg), a GABA-gated chloride ion channel blocker, antagonized the anxiolytic-like actions of A. cherimolia, while a sub-effective dose of muscimol (0.5 mg/kg), a selective GABA(A) receptor agonist, facilitated the effects of a sub-optimal dose of A. cherimolia (3.12 mg/kg). Thus, the involvement of the GABA(A) receptor complex in the anxiolytic-like actions of A. cherimolia hexane extract is suggested. In addition the extract was also able to enhance the duration of sodium pentobarbital induced sleeping time. Taken together, results indicate that the hexane extract of A. cherimolia has depressant activity on the Central Nervous System and could interact with the GABAA receptor complex. On the other hand, the chromatographic separation of this extract led to the isolation of palmitone, and beta-sitosterol as major constituents. In addition a GC-MS study of some fractions revealed the presence of several compounds such beta-cariophyllene, beta-selinene, alpha-cubebene, and linalool that have been reported to show effects on behavior that could explain some of the extract effects. (c) 2005 Elsevier Inc. All rights reserved.
机译：当给小鼠施用并在两种焦虑症动物模型中进行测试时，番荔枝番荔枝（Annona cherimolia）的己烷提取物产生类似抗焦虑的作用：小鼠回避探索行为和掩埋行为测试。为了放弃对一般活动的非特异性药物作用，在露天试验中还分析了在焦虑范式中研究的所有治疗方法。结果表明，奇异曲霉以6.25、12.5、25.0和50.0 mg / kg的剂量诱导了抗焦虑样作用。 GABA门控氯离子通道阻滞剂Pictotoxin（0.25 mg / kg）拮抗了奇异曲霉的抗焦虑作用，而亚有效剂量的麝香酚（0.5 mg / kg）是选择性GABA（A）受体。激动剂促进了次最佳剂量的奇异曲霉（3.12 mg / kg）的作用。因此，建议了GABA（A）受体复合物参与了奇异果己烷提取物的抗焦虑样作用。此外，提取物还能够延长戊巴比妥钠诱发的睡眠时间。两者合计，结果表明，奇异曲霉的己烷提取物对中枢神经系统具有抑制活性，并且可以与GABAA受体复合物相互作用。另一方面，该提取物的色谱分离导致分离出棕榈酮和β-谷甾醇作为主要成分。另外，对某些馏分的GC-MS研究表明，存在多种化合物，例如β-卡奥塔烯，β-selinene，α-cubbene和芳樟醇，据报导它们对行为有影响，可以解释某些提取物的作用。 （c）2005 Elsevier Inc.保留所有权利。

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