• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide
【24h】

Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide

机译：纳洛酮甲硫醚逆转吗啡，美沙酮和海洛因诱导的小鼠效应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Opioid overdose, which is commonly associated with opioid induced respiratory depression, is a problem with both therapeutic and illicit opioid use. While the central mechanisms involved in the effects of opioids are well described, it has also been suggested that a peripheral component may contribute to the effects observed. This study aimed to further characterise the effects of the peripherally acting naloxone methiodide on the respiratory, analgesic and withdrawal effects produced by various opioid agonists. A comparison of the respiratory and analgesic effects of morphine, methadone and heroin in male Swiss-Albino mice was conducted and respiratory depressive ED80 doses of each opioid determined. These doses (morphine 9 mg/kg i.p., methadone 7 mg/kg i.p., and heroin 17 mg/kg i.p.) were then used to show that both naloxone (3 mg/kg i.p.) and naloxone methiodide (30-100 mg/kg i.p.) could reverse the respiratory and analgesic effects of these opioid agonists, but only naloxone precipitated withdrawal. Further investigation in female C57BL/6J mice using barometric plethysmography found that both opioid antagonists could reverse methadone induced decreases in respiratory rate and increases in tidal volume. Its effects do not appear to be strain or sex dependent. It was concluded that naloxone methiodide can reverse the respiratory and analgesic actions of a variety of opioid agonists, without inducing opioid withdrawal. (c) 2005 Elsevier Inc. All rights reserved.
机译：阿片类药物过量通常与阿片类药物引起的呼吸抑制相关，是治疗和非法使用阿片类药物的问题。尽管很好地描述了阿片类药物作用的主要机制，但也有人建议外围成分可能有助于观察到的作用。这项研究旨在进一步表征外围作用的纳洛酮甲硫醇对各种阿片类激动剂产生的呼吸，镇痛和戒断作用的影响。比较了吗啡，美沙酮和海洛因对雄性Swiss-Albino小鼠的呼吸和镇痛作用，并确定了每种阿片类药物的呼吸抑制性ED80剂量。然后使用这些剂量（吗啡9 mg / kg ip，美沙酮7 mg / kg ip和海洛因17 mg / kg ip）显示纳洛酮（3 mg / kg ip）和纳洛酮（30-100 mg / kg） ip）可以逆转这些阿片类激动剂的呼吸和镇痛作用，但只有纳洛酮会引起戒断。使用气压描记法对雌性C57BL / 6J小鼠进行的进一步研究发现，两种阿片类药物拮抗剂都可以逆转美沙酮引起的呼吸频率降低和潮气量增加。它的作用似乎不取决于劳力或性别。结论是纳洛酮甲硫醇可以逆转多种阿片类激动剂的呼吸和镇痛作用，而不会引起阿片类药物停药。 （c）2005 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号