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首页> 外文期刊>Life sciences >The effects of acute corticosterone on lithium chloride-induced conditioned place aversion and locomotor activity in rats.
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The effects of acute corticosterone on lithium chloride-induced conditioned place aversion and locomotor activity in rats.

机译：急性皮质酮对氯化锂诱导的大鼠条件性厌恶和运动能力的影响。

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摘要

Acute administration of corticosterone (CORT) facilitates learning in a number of associative paradigms including lithium chloride (LiCl)-induced conditioned taste aversion learning. The present study examined the effects of acute CORT on LiCl-induced conditioned place aversions in male rats. Automated open-fields were partitioned into two chambers distinct in tactile and visual cues. Animals received either LiCl (64 mg/kg, 0.15 M) or saline (NaCl, 0.15 M) followed 10 min later by either CORT (5 mg/kg) or beta-cyclodextrin vehicle (45%) prior to placement in one of the chambers. Control rats received NaCl-Vehicle paired with both chambers. Three experimental groups received either NaCl-CORT, LiCl-Vehicle or LiCl-CORT paired with the preferred chamber and NaCl-Vehicle (control) paired with the non-preferred chamber. During extinction trials, animals were allowed to choose between the two chambers. Locomotor activity and its distribution within the chambers were assessed during both conditioning and extinction trials. CORT administration produced significant increases in a variety of measures of locomotor activity during conditioning trials. During extinction trials both LiCl groups displayed a conditioned place aversion while the NaCl-CORT group did not. In addition, significant increases in vertical activity were recorded in both LiCl groups in the LiCl-paired chamber. Moreover, CORT administration had no effect on LiCl-induced conditioned place aversion as time spent in the LiCl-paired chamber did not significantly differ between LiCl-Vehicle and LiCl-CORT groups. Significant increases in a number of measures of horizontal activity were also observed in both CORT groups. The present study shows that acute CORT administration does not significantly influence LiCl-induced conditioned place aversions and suggests that the facilitatory effects of acute CORT administration on learning are highly context-dependent.
机译：皮质酮（CORT）的急性给药可促进许多关联范例的学习，包括氯化锂（LiCl）诱导的条件性味觉厌恶学习。本研究检查了急性CORT对LiCl诱导的雄性大鼠条件性地方厌恶的影响。自动化的开放视野被划分为两个在触觉和视觉提示上不同的房间。动物接受LiCl（64 mg / kg，0.15 M）或生理盐水（NaCl，0.15 M）或10分钟后接受CORT（5 mg / kg）或β-环糊精载体（45％）的治疗，然后再置于其中一种庭。对照大鼠接受与两个腔室配对的NaCl-载体。三个实验组接受与优选腔室配对的NaCl-CORT，LiCl-车辆或LiCl-CORT，以及与非优选腔室配对的NaCl-车辆（对照）。在灭绝试验期间，允许动物在两个房间之间进行选择。在调节和消光试验期间，评估运动能力及其在室内的分布。在调节试验期间，CORT给药使运动活动的各种指标均显着增加。在灭绝试验中，两个LiCl组均表现出条件厌恶，而NaCl-CORT组则没有。另外，在LiCl配对室中的两个LiCl组中记录到垂直活性的显着增加。此外，CORT给药对LiCl诱导的条件场所厌恶没有影响，因为在LiCl车辆和LiCl-CORT组之间在LiCl配对室中花费的时间没有显着差异。在两个CORT组中，也观察到许多水平活动量的显着增加。本研究表明，急性CORT施用对LiCl诱导的条件性场所厌恶没有明显影响，并表明急性CORT施用对学习的促进作用高度依赖于情境。

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