• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats.
【24h】

Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats.

机译：依托昔布和曲马多对大鼠脊髓机械性痛觉过敏的相互作用分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Drug combinations have the potential advantage of greater analgesia over monotherapy. The present study was aimed to assess any possible interaction (additive or potentiation) in the antinociceptive effects of etoricoxib; a novel cyclooxygenase-2 inhibitor, and tramadol; a typical opioid agonist when administered in combination against mechanical hyperalgesia induced by spinal cord injury in rats. The nature of interaction was analyzed using surface of synergistic interaction (SSI) analysis and an isobolographic analysis. Etoricoxib or tramadol when administered alone to rats, exhibited different antihyperalgesic potencies (ED50 etoricoxib: 0.58+/-0.19 mg/kg, po; ED50 tramadol: 9.85+/-0.57 mg/kg, po). However, both the drugs were found to be long acting against this model of hyperalgesia. Further, etoricoxib and tramadol were co-administered in fixed ratios of ED50 fractions. One combination (0.29/4.79 mg/kg, po: etoricoxib/tramadol) exhibited additivity and other three combinations (0.15/2.39, 0.08/1.19, and 0.04/0.59 mg/kg, po: etoricoxib/tramadol) resulted in potentiation when analyzed by SSI. The SSI was calculated from the total antihyperalgesic effect produced by the combination after the subtraction of the antihyperalgesic effect produced by each of the individual drug. In the isobolographic analysis, the experimental ED50 was found to be far below the line of additivity also indicating a significant (P < 0.05) synergistic antihyperalgesic effect when etoricoxib and tramadol was co-administered to rats. The synergistic antihyperalgesic effect of etoricoxib and tramadol combination suggests that these combinations may have clinical utility in mechanical hyperalgesia associated with spinal injury.
机译：与单一疗法相比，药物组合具有更大镇痛的潜在优势。本研究旨在评估依托昔布的抗伤害感受作用中任何可能的相互作用（加性或增强作用）。一种新型的环氧合酶-2抑制剂和曲马多;当与大鼠脊髓损伤所致的机械性痛觉过敏合用时，是一种典型的阿片类激动剂。使用表面协同作用分析（SSI）和等效线描写法分析了相互作用的性质。单独对大鼠给药时，依托昔布或曲马多的抗痛觉过敏能力不同（ED50依托昔布：0.58 +/- 0.19 mg / kg，口服; ED50曲马多：9.85 +/- 0.57 mg / kg，口服）。但是，发现这两种药物对这种痛觉过敏模型均具有长期作用。此外，依托考昔和曲马多以固定比例的ED50比例共同给药。一种组合（0.29 / 4.79 mg / kg，po：依托考昔/曲马多）具有可加性，而其他三种组合（0.15 / 2.39、0.08 / 1.19和0.04 / 0.59 mg / kg，po：依托考昔/曲马多）在分析时具有增强作用由SSI。从减去每种药物产生的抗痛觉过敏作用后，通过组合产生的总抗痛觉过敏作用计算SSI。在等效线描记法分析中，发现实验性ED50远低于可加性线，这还表明当将依托昔布和曲马多共同给药于大鼠时，具有显着的（P <0.05）协同抗痛觉过敏作用。依托昔布和曲马多组合的协同抗痛觉过敏作用表明，这些组合可能在与脊髓损伤相关的机械性痛觉过敏中具有临床效用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号