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首页> 外文期刊>Life sciences >Pharmacological basis of 'Yin-nourishing' and 'Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb.
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Pharmacological basis of 'Yin-nourishing' and 'Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb.

机译：冬虫夏草的“滋阴”和“补阳”作用的药理基础。

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Cordyceps sinensis (Berk.) Sacc. (Cordyceps), a popular Chinese tonifying herb, was revered for being both 'Yin-nourishing' and 'Yang-invigorating' in Chinese medicine. In order to establish the pharmacological basis for the 'Yin-nourishing' and 'Yang-invigorating' action of Cordyceps, the effects of wild and cultured Cordyceps on concanavalin A (Con A)-stimulated splenocytes, an in vitro bioassay for 'Yin-nourishment', and myocardial ATP generation capacity, an ex vivo bioassay for 'Yang-invigoration', were investigated in mice. The results indicated that methanolic extracts of wild and cultured Cordyceps enhanced both the Con A-stimulated splenocyte proliferation in vitro and myocardial mitochondrial ATP generation ex vivo in mice, with no significant difference in potency of action between the two types of Cordyceps. While the immuno-potentiating effect was associated with the increase in interleukin II production, the stimulation of myocardial ATP generation was paralleled by an enhancement in mitochondrial electron transport. When compared with typical 'Yin' and 'Yang' tonifying Chinese herbs, Cordyceps was found to possess both 'Yin-nourishing' and 'Yang-invigorating' activities, with a lower potency in both modes of action. The pharmacological characterization of Cordyceps by means of contemporary bioassays is consistent with the time-honored clinical observation from Chinese herbalists.
机译：冬虫夏草（比利时）Sacc。冬虫夏草（Cordyceps）是一种受人欢迎的中药，因其在中药中既“滋阴”又“养阳”而备受推崇。为了建立冬虫夏草的“滋阴”和“补阳”作用的药理基础，野生和培养的冬虫夏草对伴刀豆球蛋白A（Con A）刺激的脾细胞的影响，这是一种体外生物测定“阴-”的方法。在小鼠中研究了“营养”和心肌ATP生成能力，这是一种“养阳”的离体生物测定方法。结果表明，野生和培养的冬虫夏草的甲醇提取物均能增强Con A刺激的小鼠脾细胞的体外增殖和离体小鼠心肌线粒体ATP的生成，两种冬虫夏草的作用力无显着差异。虽然免疫增强作用与白介素II产生的增加有关，但心肌ATP产生的刺激与线粒体电子传递的增加平行。与典型的滋补中草药的“阴”和“阳”相比，冬虫夏草同时具有“滋阴”和“补阳”的作用，在两种作用方式中的效力均较低。通过现代生物测定法对冬虫夏草进行药理学鉴定，与中草药学家长期以来的临床观察一致。

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