• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed)
【24h】

Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed)

机译：传统抗糖尿病植物plant树（Sweet Broomweed）的胰岛素分泌反应活性和细胞保护作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Scoparia dulcis (Sweet Broomweed) has been documented as a traditional treatment of diabetes. The administration of an aqueous extract of Scoparia dulcis at a dose of 200 mg/kg body weight significantly decreased the blood glucose with significant increase in plasma insulin level in streptozotocin diabetic rats at the end of 15 days treatment. The insulin secretagogue action of Scoparia dulcis plant extract (SPEt) was further investigated using isolated pancreatic islets from mice. SPEt at a dose of 10 mug/ml evoked 6.0 fold stimulation of insulin secretion from isolated islets indicating its insulin secretagogue activity. In addition the effect of SPEt on streptozotocin induced cell death and nitric oxide (NO) in terms of nitrite production were also examined. SPEt protected against streptozotocin- mediated cytotoxicity (88%) and NO production in rat insulinoma cell line (RINm5F). Above results suggest the glucose lowering effect of SPEt to be associated with potentiation of insulin release from pancreatic islets. Our results revealed the possible therapeutic value of Scoparia dulcis for the better control, management and prevention of diabetes mellitus progression. (C) 2004 Elsevier Inc. All rights reserved.
机译：Scoparia dulcis（Sweet Broomweed）已被记录为糖尿病的传统治疗方法。在治疗的第15天结束时，链脲佐菌素糖尿病大鼠以200 mg / kg体重的剂量服用Scoparia dulcis的水提取物可显着降低血糖，并显着增加血浆胰岛素水平。使用分离自小鼠的胰岛进一步研究了苦参植物提取物（SPEt）的胰岛素促分泌作用。剂量为10杯/毫升的SPEt引起离体胰岛胰岛素分泌的6.0倍刺激，表明其胰岛素促分泌活性。此外，还检查了SPEt对链脲佐菌素诱导的细胞死亡和一氧化氮（NO）产生亚硝酸盐的影响。 SPEt可防止链脲佐菌素介导的细胞毒性（88％）和大鼠胰岛素瘤细胞系（RINm5F）中NO的产生。以上结果表明，SPEt的降糖作用与增强胰岛中胰岛素的释放有关。我们的研究结果揭示了苦参对更好地控制，管理和预防糖尿病进展的可能的治疗价值。 （C）2004 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号