• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Does melatonin modulate beta-endorphin, corticosterone, and pain threshold?
【24h】

Does melatonin modulate beta-endorphin, corticosterone, and pain threshold?

机译：褪黑激素会调节β-内啡肽，皮质酮和疼痛阈值吗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Converging lines of evidence suggest that the pineal hormone, melatonin, may regulate changes in pain threshold by modulating fluctuations in opioid receptor expression and levels of beta-endorphin (beta-END). This study investigated whether the circadian oscillation in plasma melatonin is involved in the modulation of plasma beta-END immunoreactivity (beta-END-ir), and whether fluctuations in pain threshold measured using the hotplate test are contingent upon the fluctuation of these two hormones in Rattus Norvegicus. The role of melatonin was explored using light-induced functional pinealectomy (LFPX) to suppress nocturnal melatonin release. Pinealectomized rats were found to have significantly elevated levels of beta-END-ir compared to control animals at both photophase (398 +/- 89 pg/ml versus 180 +/- 23 pg/ml) and scotophase (373 +/- 45 pg/ml versus 203 +/- 20 pg/ml) test-periods, thus supporting the putative melatonin-opioid axis. Similarly, latency to pain threshold of LFPX rats was significantly longer when compared to control animals at photophase (7.3 +/- 1.4 sec versus 4.8 +/- 0.7 sec) and scotophase (6.3 +/- 0.7 sec versus 5.1 +/- 0.7 sec). Previous studies have produced conflicting data regarding the role of the pineal system in modulating levels of corticosterone (CORT). We observed a moderate, but non-significant, increase in the CORT concentration of LFPX rats during the photophase test period.
机译：越来越多的证据表明，松果激素褪黑激素可能通过调节阿片受体表达和β-内啡肽（β-END）水平的波动来调节疼痛阈值的变化。这项研究调查了血浆褪黑激素的昼夜节律振荡是否参与血浆β-END免疫反应性（β-END-ir）的调节，以及使用热板试验测量的疼痛阈值波动是否取决于这两种激素的波动。褐家鼠使用光诱导功能性松果体切除术（LFPX）探索了褪黑素的作用，以抑制夜间褪黑素的释放。与对照动物相比，在光相阶段（398 +/- 89 pg / ml与180 +/- 23 pg / ml）和暗期（373 +/- 45 pg），与对照组动物相比，经松散切除术的大鼠的β-END-ir水平明显升高/ ml与203 +/- 20 pg / ml的测试期间），从而支持假定的褪黑素-阿片样物质轴。类似地，与对照动物相比，LFPX大鼠的疼痛阈值潜伏期明显更长（7.3 +/- 1.4秒与4.8 +/- 0.7秒对立）和暗相（6.3 +/- 0.7秒与5.1 +/- 0.7秒对立） ）。先前的研究产生了相互矛盾的数据，这些数据涉及松果体系统在调节皮质酮（CORT）水平中的作用。我们观察到在光相测试期间，LFPX大鼠的CORT浓度出现了适度但不显着的升高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号