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首页> 外文期刊>Life sciences >Effect of epidermal growth factor on intestinal adaptation after allogeneic small bowel transplantation in rats.
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Effect of epidermal growth factor on intestinal adaptation after allogeneic small bowel transplantation in rats.

机译：表皮生长因子对异基因小肠移植后大鼠肠道适应的影响。

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摘要

We reported that epidermal growth factor (EGF) stimulated graft adaptation in a rat model of syngeneic small bowel transplantation. However, graft rejection is a severe problem with clinical small bowel transplantation, because small intestinal wall contains large amounts of lymphoid tissue. Studies were performed to investigate the effect of EGF on allogeneic graft adaptation after small bowel transplantation in rats treated with an immunosuppressant FK506. The transplanted animals received intraperitoneally EGF or saline (untreated) after surgery and were examined for analysis one week later. EGF-treated group markedly enhanced the water absorption and induction of sodium glucose cotransporter (SGLTI) as compared with EGF-untreated group. EGF-treated group also increased the mucosal crypt depth and its cell proliferating rate, although there was no significant difference in the mucosal villus height between the two groups. These results indicate that EGF accelerates intestinal allograft adaptation in part by the recovery of mucosal structure and function after small bowel transplantation in rats. EGF may have relevance to promote graft function in clinical small intestinal transplantation.
机译：我们报道表皮生长因子（EGF）刺激同基因小肠移植大鼠模型中的移植适应。然而，由于小肠壁包含大量淋巴组织，因此移植排斥对于临床小肠移植是一个严重的问题。进行了研究，以研究在用免疫抑制剂FK506治疗的大鼠小肠移植后EGF对同种异体移植物适应的影响。移植后的动物在手术后接受腹膜内EGF或生理盐水（未治疗），并在一周后接受分析检查。与未用EGF处理的组相比，用EGF处理的组显着提高了钠葡萄糖共转运蛋白（SGLTI）的吸水率和诱导。 EGF治疗组也增加了粘膜隐窝深度及其细胞增殖速率，尽管两组之间的粘膜绒毛高度没有显着差异。这些结果表明，EGF在大鼠小肠移植后通过部分粘膜结构和功能的恢复来加速肠道同种异体移植适应。 EGF在临床小肠移植中可能具有促进移植功能的作用。

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