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首页> 外文期刊>Life sciences >TIMPs and MMPs expression in CSF from patients with TSP/HAM.
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TIMPs and MMPs expression in CSF from patients with TSP/HAM.

机译：TSP / HAM患者脑脊液中TIMPs和MMPs的表达。

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摘要

The tropical spastic paraparesis or human T-cell lymphotropic virus associated myelopathy (TSP/HAM), has been related with an overexpression of matrix metalloproteinases (MMPs), especially MMP-9. Initial studies of reverse zymography with cerebrospinal fluid (CSF) from TSP/HAM patients, and controls showed the presence of TIMPs, endogenous MMP inhibitors. We determined in CSF the levels of TIMPs by immunoanalysis in 25 patients with TSP/HAM, and compared with two groups: controls and patients with acute and subacute inflammatory neurological diseases. We found that TIMP-2, TIMP-3 and TIMP-4 levels were significantly higher than in controls in both TSP/HAM and inflammatory patients, while TIMP-1 was increased only in the inflammatory group. Levels of MMP-3 and MMP-9 from the two groups of patients showed a significant upregulation in CSF. In the CSF of around the 70% of TSP-HAM and inflammatory patients the presence MMP-9 was detected by zymography, but not in controls. MMP-2 was only overexpressed in the acute inflammatory group. The active form of MMP-2 was observed in both groups of patients with a similar high frequency (60%). MMPs overexpressions are independent of the evolution time of the disease in TSP/HAM. The chronic overexpression of these extracelullar matrix proteins detected in CSF of TSP/HAM should be indirectly produced by secreted viral proteins being responsible for the progression of this disease, accounting for the observed differences with acute inflammatory patients. Our results support the existence of an imbalance between MMPs and their endogenous tissue inhibitors, which could be a pathogenic factor in the chronicity of TSP/HAM.
机译：热带痉挛性轻瘫或人T细胞淋巴病毒相关性脊髓病（TSP / HAM）与基质金属蛋白酶（MMPs），尤其是MMP-9的过表达有关。来自TSP / HAM患者和对照组的脑脊液（CSF）反向酶谱学的初步研究显示，存在内源性MMP抑制剂TIMPs。我们通过免疫分析在CSF中确定了25例TSP / HAM患者的TIMPs水平，并与两组进行比较：对照组和急性及亚急性炎性神经疾病患者。我们发现，TSP / HAM和炎性患者的TIMP-2，TIMP-3和TIMP-4水平均显着高于对照组，而TIMP-1仅在炎性组中增加。两组患者的MMP-3和MMP-9水平显示脑脊液显着上调。在大约70％的TSP-HAM和炎性患者的CSF中，通过酶谱法检测到MMP-9的存在，但在对照中未检测到。 MMP-2仅在急性炎症组中过表达。在两组患者中均以相似的高频率（60％）观察到了MMP-2的活性形式。 MTS的过度表达与TSP / HAM中疾病的演变时间无关。在TSP / HAM的CSF中检测到的这些胞外基质蛋白的慢性过表达应该由分泌病毒的蛋白质间接产生，该病毒负责该疾病的发展，这是与急性炎症患者观察到的差异有关的。我们的研究结果支持MMP及其内源性组织抑制剂之间不平衡的存在，这可能是TSP / HAM慢性病的致病因素。

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